主要效果终端指标为总生存率和症状进展时间。
Primary efficacy endpoints were overall survival and time to symptomatic progression.
在疾病早期，视网膜病没有明显的症状，但是随着时间的推移能进展到一个阶段：眼血管渗漏断裂，甚至致盲。
In its earliest stages, retinopathy often has no overt symptoms but can progress over time to a phase in which the blood vessels of the eye leak and rupture easily, eventually causing blindness.
在开始进入研究后，比起中等与快速进展患者，智商与所受教育水平更高的低进展患者也有了更长的所估测的症状持续时间。
At study entry, the slow progressors also had a longer estimated duration of symptoms than intermediate or fast progressors, as well as higher IQ and education.
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