③Recombinant salmonella typhimurium were successfully constructed;attenuated salmonella typhimurium showed stability in carrying the plasmids and invasiveness against B 16 cells,and could express proteins encoded by target genes in B16 cells.
③重组沙门菌构建成功,减毒沙门菌携带质粒具有稳定性,对小鼠黑色素B16肿瘤细胞具有侵袭性并能在B16细胞中表达目的基因的蛋白。
参考来源 - 减毒沙门菌介导mtHSP70/HSV·2,447,543篇论文数据，部分数据来源于NoteExpress
减毒的沙门氏菌是一种非病原性细菌，能靶向肿瘤并产生局部抗肿瘤的效应。
Attenuated salmonella is a group of non-pathogenic bacteria that can target tumors and has local anti-tumor effects.
结论：口服减毒沙门氏菌sl 3261为载体的PF 4基因可以保护小鼠免受损伤，并促进化疗损伤小鼠的造血恢复。
Conclusions: Oral attenuated Salmonella Typhmuriumas SL3261 transfected with PF4 gene can protect mice from injury and promote the hematopoiesis reconstitution of chemotherapy injured mice.
减毒鼠伤寒沙门菌由于具有肿瘤靶向性，能在肿瘤组织中复制并产生抗肿瘤效果的能力，使肿瘤治疗获得了新契机。
Considering its tumor targeting, replication in tumor tissues and anti-tumor effects, attenuated Salmonella typhimurium has offered a new approach to tumor therapy.
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