同时，该条约也对欧盟这个全球最大的经济联合体提出了许多重大问题，如：欧洲成为“国家联盟”是否已是不可避免？
It also poses serious questions about the world's biggest economy. Is Europe evolving inexorably into a federation of states?
中美在事关全球稳定与繁荣的众多重大问题上，拥有更加广泛的合作基础，肩负更加重要的共同责任。
The United States and China have anincreasingly broadbase of cooperation and share increasinglyimportant commonresponsibilities on many major issues concerningglobal stability andprosperity.
艾滋病是全球关注的重要公共卫生和社会热点问题，同时它也是关乎人口安全的重大问题之一。
AIDS is a global issue concerning important public health and social hot problems, and one of the important issues of population security as well.
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