Bafetimbi Gomis lobbed in the fourth after heading the ball past Debrecen goalkeeper Vukasin Poleksic early in the second half, as Lyon established a three-point lead over Liverpool and Fiorentina at the top of the group.
In 2010, UEFA banned Debrecen goalkeeper Vukasin Poleksic for two years for failing to report that he was approached to fix matches by a betting syndicate before a match against Fiorentina in October the previous year.