Chile, shorn of suspended trio Marco Estrada, Waldo Ponce and Gary Medel, were always up against it after conceding twice in four minutes shortly after the half-hour mark.
In a rare struggle to monopolise the ball, Spain looked riled - but while Chile worked overtime to establish the upper hand they lost their discipline - both Gary Medel and Waldo Ponce were rightly booked for nasty tackles and will miss the match against Brazil.