目的探讨醋甲唑胺对青光眼的治疗价值。
Objective To study the therapeutic effect of methazolamide on glaucoma.
乙酰唑胺、醋甲唑胺、双氯非那胺等碳酸酐酶抑制剂自1954年起就被应用于青光眼的降眼压治疗。
Carbonic anhydrase inhibitors (CAIs) were first used to lower intraocular pressure (IOP) in glaucoma in 1954, with the introduction of acetazolamide, methazolamide and diclofenamide were subsequently.
结果表明，醋甲唑胺的眼用混悬剂可以显著提高药物在眼内的生物利用度，达到了局部用药制剂的设计要求。
These results indicate that the ophthalmic suspensions increased the bioavailability of MTZ in the eye aqueous humor, which is of significance in the development of topical dosage form of MTZ.
结果表明，醋甲唑胺的眼用混悬剂可以显著提高药物在眼内的生物利用度，达到了局部用药制剂的设计要求。
These results indicate that the ophthalmic suspensions increased the bioavailability of MTZ in the eye aqueous humor, which is of significance in the development of topical dosage form of MTZ.
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