通过 caspase-3 剪切的Actin可能加速蛋白酶体依赖的肌肉蛋白水解。
Actin cleavage by caspase-3 may accelerate proteosome dependent muscle proteolysis.
PS 341是蛋白酶体有效的选择性抑制药。
PS 341 is a potent and selective inhibitor of the proteasome.
EIN3受到蛋白酶体介导的蛋白降解途径的调节。
EIN3 is regulated by a proteasome-mediated protein degradation pathway.
泛素蛋白酶体途径是真核生物最普遍的调控过程之一。
The ubiquitin-proteasome pathway is now considered as one of the most common regulatory processes in all eukaryotes.
波替单抗(万珂)是第一个进入临床试验的蛋白酶体抑制剂。
Bortezonib (velcade) is the first proteasome inhibitor that has entered clinical trial.
目的：研究泛素蛋白酶体抑制剂对胃癌细胞增殖和凋亡的影响。
AIM: to investigate effects of ubiquitin-proteasome inhibitor on proliferation and apoptosis of gastric carcinoma cells.
蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡，逆转多药耐药。
Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.
目的：探讨泛肽蛋白酶体对TRAIL诱导细胞凋亡作用的影响。
Objective To determine the influence of ubiquitin-proteasome in regulating the TRAIL-mediated apoptosis.
此外，对化疗有反应的患者在治疗后蛋白酶体水平有显著的降低。
In addition, following chemotherapy, there was a significant decrease in proteasome levels in patients who responded compared to those who did not.
泛素是一种保守的多肽单元，在泛素蛋白酶体途径中起重要作用。
Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway.
目的分离纯化正常大鼠脾脏2 0S蛋白酶体，并观察其形态特征。
Objective To isolate and purify 20S proteasome from normal rat spleen and observe its morphologic features.
药效学分析表明蛋白酶体抑制药的抑制作用有剂量依赖性和可逆性。
Pharmacodynamic assay has shown that inhibition of proteasome is dose dependent and reversible.
用蛋白酶体抑制剂抑制可以明显阻断肌细胞MHC I分子的表达；
The expression of MHC I molecules on the muscle cells can be inhibited by the proteasome inhibitors lactacystin and MG132.
本文对蛋白酶体的组成结构、病理生理作用和现有抑制剂进行归纳总结。
This review summarizes composition and structure of proteasome, its physiological and pathological actions, and available inhibitors.
蛋白酶体是细胞的蛋白质降解机制，由一个核心颗粒和两个调节颗粒组成。
The proteasome is essential for the selecive degradation of most cellular proteins, but how cells maintain adequate amounts of proteasome is unclear.
蛋白酶体是真核细胞中含量丰富的多酶复合物，它主要协助降解细胞内的蛋白。
The proteasome is an abundant multi-enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells.
蛋白酶体的抑制在肿瘤的信号通路定向治疗方面已经成为一个极其有希望的途径。
Inhibition of proteasome has been emerging as a promising approach in pathway-directed cancer therapy.
另外，可变的蛋白酶体功能与细胞活力下降无关，而与蛋白氧化水平的升高有关。
Furthermore, the altered proteasome functionality is not associated with a decrease in cell viability, but is linked with increased levels of protein oxidation.
蛋白酶体是存在与真核细胞的细胞核和细胞质中的含量丰富且有催化作用的复合物。
The proteasome is an abundant, catalytic complex that is found in both the nucleus and cytoplasm of eukaryotic cells.
本文综述蛋白酶体在细胞信号转导中的生物学功能和在神经退行性疾病中的可能作用。
This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases.
目的探讨蛋白酶体抑制剂MG- 132对体外人u87胶质瘤细胞增殖和凋亡的影响。
Objective to explore the effects of proteasome inhibitor MG-132 on proliferation, apoptosis of U87 glioma cells in vitro.
目的研究蛋白酶体抑制剂PSI诱导PC12细胞胞浆内嗜酸性包涵体的形成及演变过程。
Objective To study the formation and development of inclusions in dopaminergic PC12 cells treated with proteasome inhibitor PSI.
我们正在分析107基因调控叶的极性建成的分子机理及其与26s蛋白酶体之间的关系。
We are studying the underlying mechanisms of leaf polarity formation regulated by 107 gene and the relationship between 107 and 26s proteasome.
泛素- 蛋白酶体途径介导的蛋白降解是机体调节细胞内蛋白水平与功能的一个重要机制。
Protein degradation mediated by ubiquitin-proteasome pathway is an important mechanism which modulates cellular proteins′ activity and function.
一些有前景的药物如沙利度胺、蛋白酶体抑制剂、砷剂等的应用使MM的治疗得到了极大的突破。
Applications of several perspective drugs such as Thalidomide, proteasomes inhibitor, arsenical and other agents bring galactic breakthrough to the treatments of MM.
通过caspase-3剪切的Actin可能加速泛素/蛋白酶体依赖的肌肉蛋白水解（6）。
Actin cleavage by caspase-3 may accelerate ubiquitin/proteosome dependent muscle proteolysis (6).
进而，采用流式细胞技术研究了不同蛋白酶体抑制剂以及TAP对噬菌体颗粒抗原交叉呈递的影响。
Furthermore, the effect of proteasome inhibitors and TAP on particle antigens cross presentation was investigated by FACS analysis.
泛素蛋白酶体途径是调节多种细胞生物学过程的重要机制，也是恶性肿瘤相关调节异常的潜在靶点；
Ubiquitin-proteasome pathway is an important mechanism regulating many processes of cellular biology, and also a potential target for abnormal regulation associated with malignancy.
越来越多的研究表明了这种蛋白与蛋白酶体——细胞内蛋白酶机械，特别是泛素-蛋白酶体的相关性。
Increasing evidence has identified a correlation between this protein and the proteasome, the cellular proteolytic machinery, in particular the ubiquitin-proteasome system.
越来越多的研究表明了这种蛋白与蛋白酶体——细胞内蛋白酶机械，特别是泛素-蛋白酶体的相关性。
Increasing evidence has identified a correlation between this protein and the proteasome, the cellular proteolytic machinery, in particular the ubiquitin-proteasome system.
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