目的：为了促进药物代谢酶在临床上的深入研究。
Objective: To promote the study of drug metabolic enzymes in clinical practice.
目的：综述近年来中药有效成分对药物代谢酶的影响的研究进展。
Objective: To review the effects of the active components of Chinese herbs on drug metabolizing enzymes.
目的观察粗叶悬钩子粗多糖对模型大鼠急性肝损伤药物代谢酶的影响。
Objective To investigate the effect of polysaccharide of Rubus alceaefolius Poir on drug-metabolizing enzyme in acute liver injury rats.
结论：药物代谢酶的认识和研究有助于临床合理用药和减少药物不良反应。
Conclusion: the study of drug metabolic enzymes will help to provide safe, rational and effective prescriptions and to decrease the adverse drug reactions.
肠道转运体、肝脏药物代谢酶及肾脏在药物adme过程中发挥着重要作用。
Intestinal drug transporters, hepatic drug metabolic enzymes and the kidney play a very important role in the process of ADME.
结果提示镉、铅、汞可能通过降低微粒体酶的新生合成，抑制肝微粒体药物代谢酶。
The results suggested that the inhibition of hepatic microsomal drug-metabolizing enzymes by cadmium, lead or mercury was produced by decreased neosynthesis of microsomal enzymes.
通过比较，发现凝胶包埋细胞比单层贴壁培养细胞能更好地保持各项药物代谢酶的活性。
By comparison of enzyme activitys in gel entrapment and monolayer culture, it was concluded that cells of gel entrapment can maintain these enzyme activity better than those of monolayer.
药物代谢酶、转运体及药物作用靶点存在着的基因多态性与药物疗效和毒性的个体差异有很大关系。
The genetic polymorphism of drug metabolizing enzyme, transporter and target greatly influence the individual difference of drug efficiency and toxicity.
氧化苦参碱是自中药苦参中提取的一种生物碱，本文就其对小鼠肝微粒体药物代谢酶的影响进行了探讨。
The effect of Oxymatrine(OMT), isolated from Sophora flavescens Ait, on the hepatic microsomal drug-metabolism enzyme have been investigated.
目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。
Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients.
本发明公开了一种食蟹猴P 4502e1药物代谢酶及其与食蟹猴p450氧化还原酶的共表达的重组载体。
The invention discloses a recombinant vector co-expressed by medicament metabolizing enzyme P450 2e1 of cynomolgus monkey and REDOX enzyme P450 of cynomolgus monkey.
肝脏微粒体细胞色素P - 450依赖性药物代谢酶(简称MCP - 450)系统和免疫系统是重要的防御体系。
While the microsome cytochrome P450dependent drug metabolic enzyme (MCP450) in liver is organism's defense system to lipid foreign body.
药物代谢酶(DME)在药物代谢解毒和药物代谢活化中起着重要的作用，对组织器官的药物效应和毒性的易感性产生重要影响。
Drug metabolism enzymes (DME) play a significant role in drug detoxification and activation, which exert important effect on drug efficacy and sensitivity to toxicity.
本文以风湿性疾病常用的治疗药物为主线，归纳了近年来影响药物疗效中有关药物代谢酶、药物转运体和药物作用靶点的基因组学研究进展。
The progress of pharmacogenomic research in the effects of drug treatment on rheumatic diseases could prevent adverse reactions, and provide reasonable guidance to clinical treatment.
人群中DNA存在多态性，与药物反应相关的基因多态性可能产生药物效应的个体差异，例如药物代谢酶、药物作用受体以及其它一些与疾病相关基因等。
Polymorphisms exist in human genomic DNA. And some polymorphisms such as metabolic enzymes, drug receptors, and some other genes correlated with diseases may affect the drug responsiveness.
根据动物实验来预测人体的药物代谢时，代谢酶的种属差异性会使这项研究工作变得非常困难。
Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes.
通过高效液相色谱法检测探针药物的代谢率，评价各组CYP450酶的活性水平。
To evaluate the activity of CYP450 in different groups, the metabolic rate of cocktail probe drugs was determined by HPLC.
CYP3A29是猪肝脏最重要的药物代谢关键酶。
CYP3A29 is the most important key enzyme for drug metabolism in pig's liver.
这次综述提供了一个对大多数药物代谢有关的酶为重点的细胞色素P 450系统的了解。
This review provides a better understanding of the cytochrome P450 system with a focus on those enzymes most involved in drug metabolism.
酶促代谢不只通过单一途径，每个人酶活力不一，可表现为药物效应的个体差异。
The knowledge of metabolism of a drug is thus essential in the course of development as well as for its safe uses.
结论杆状病毒表达系统能成功表达有活性的CYP2B6重组酶，可用来进一步研究在药物代谢中的作用。
CONCLUSION Active recombinant human CYP2B6 obtained using baculovirus expression system will facilitate further examination of the role of this enzyme in drug metabolism.
方法：综述近几年具遗传多态性代谢酶的探针药物、代谢分型方法以及影响因素。
METHOD:The probe drugs of drug metabolism, methods of phenotype and related factors were reviewed.
多年来，对细胞色素酶P 4 5 0的研究主要集中在其代谢外源性药物和毒物的方面。
For many years, researches on Cytochrome P450 had been focused on their roles in exogenous drugs and poisons metabolism.
CYP450的合成受着遗传基因的调控，一旦基因发生变异，它所调控合成的CYP450酶及酶所催化的药物代谢即发生变化。
CYP450 is regulated by genetic genes. Once the gene mutates, the CYP450 enzyme that coded and the drug metabolism then will change.
细胞色素P 450和谷胱甘肽s转移酶是二组参于抗肿瘤药物和致癌剂代谢的重要酶系。
Cytochrome P450 and GST are two important complex gene families of enzymes that metabolize therapeutic drugs and carcinogens.
细胞色素氧化酶p 4501a2 (CYP1A2)在药物代谢、前致癌物激活的过程中起重要的作用。
Cytochrome P4501A2 (CYP1A2) plays a critical role in the oxidative metabolism of a variety of exogenous compounds such as drugs, environmental procarcinogens and other xenobiotics.
细胞色素P 4503A (CYP3A)是参与临床药物代谢的主要CYP同工酶之一。
Cytochrome P450 3a (CYP3A) is one of the key isoenzymes involved in the metabolism of clinical drugs.
认识药物代谢的酶学基础，了解药酶的常见底物、诱导剂和抑制剂，合理选用同类药品，能避免有害药物代谢性相互作用的发生。
The adverse drug interactions can be avoided by knowing the enzymology basis of drug metabolism, common substrates, inductors, inhibitors involved and using the same kind of drugs rationally.
目的：观察大鼠急性心肌梗死后心肌局部基质金属蛋白酶2和9的变化与胶原代谢的关系，并探讨药物辛伐他汀的干预作用。
AIM To observe the relation of changes of matrix metalloproteinase 2 and 9 MMPs-29 and the collagen metabolism and explore the intervention effect of simvastatin.
目的：观察大鼠急性心肌梗死后心肌局部基质金属蛋白酶2和9的变化与胶原代谢的关系，并探讨药物辛伐他汀的干预作用。
AIM To observe the relation of changes of matrix metalloproteinase 2 and 9 MMPs-29 and the collagen metabolism and explore the intervention effect of simvastatin.
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