综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。
The pharmacological actions of histone deacetylase inhibitors and their potential clinical use…
综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。
The pharmacological actions of histone deacetylase inhibitors and their potential clinic…
组蛋白去乙酰酶抑制剂降低抗原提呈小鼠骨髓来源的树突状细胞的活性。
Histone deacetylase inhibitors decrease the antigen presenting activity of murine bone marrow derived dendritic cells.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平，并对一些非组蛋白成分产生影响，从而调节某些特定基因的表达。
Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins, and specifically modulate some gene expression.
他们发现，大脑中有一个“开关”控制瘦素的作用，它就是一种名为组蛋白去乙酰化酶5（HDAC5）的酶。
They have discovered an enzyme - histone deacetylase 5 (HDAC5) - has a significant influence on the effect of the hormone.
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
目的：探讨组蛋白去乙酰化酶抑制剂MS- 275诱导人多发性骨髓瘤细胞株u266凋亡的分子机制。
OBJECTIVE: to investigate the molecular mechanisms of histone deacetylase inhibitor MS-275 on apoptosis of human myeloma U266 cell line.
本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述。
In this paper, we reviewed the mechanisms on histone acetyltransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
认识到开发新颖治疗剂的要求，本发明提供新颖组蛋白去乙酰化酶抑制剂。
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
本文综述了丁酸和植物提取物等饲料添加剂作为组蛋白去乙酰化酶(HDAC)抑制剂在模型动物及畜禽上的研究进展。
This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).
目的研究组蛋白去乙酰化酶抑制剂MS275对人多发性骨髓瘤细胞U266增殖的影响。
ObjectiveTo investigate the antitumor effect of MS275, a histone deacetylase inhibitor, on growth of the human myeloma cell line U266.
研究人员经过实验发现，通过去除哺乳动物细胞中的PSF或sin3 -组蛋白去乙酰化酶复合物，他们能够缩短生物钟周期的长度。
The researchers found that they could shorten the length of the circadian cycle by removing PSF or SIN3-histone deacetylase complex from mammalian cells.
抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂，临床 上用于治疗皮肤T细胞淋巴瘤。
Romidepsin is a potent histone deacetylase inhibitor, and is used in the treatment of cutaneous T-cell lymphoma (CTCL).
抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂，临床 上用于治疗皮肤T细胞淋巴瘤。
Romidepsin is a potent histone deacetylase inhibitor, and is used in the treatment of cutaneous T-cell lymphoma (CTCL).
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