采用HPLC MS法测定给药后不同时间丙酸红霉素和红霉素碱的血药浓度。
The concentrations of erythromycin propionate and erythromycin base in the plasma were determined by HPLC-MS.
红霉素碱经肟化、保护再经甲基化、脱保护得到克拉霉素，总收率达40 %以上。
Clarithromycin was prepared from erythromycin a through oximation, protection, methylation and deprotection. The overall yield of clarithromycin was 40%.
红霉素碱经肟化、保护再经甲基化、脱保护得到克拉霉素，总收率达40 %以上。
Clarithromycin was prepared from erythromycin a through oximation, protection, methylation and deprotection. The overall yield of clarithromycin was 40%.
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