极光激酶A参与中心体分离、成熟和纺锤体组装及稳定。
Aurora a is involved in centrosome separation, maturation, and spindle assembly and stability.
该药物称为极光激酶抑制剂-改善小鼠化疗时候的存活率。
The drug - called an Aurora kinase inhibitor - improved survival for mice when combined with chemotherapy.
在不同的模式生物中，极光激酶各家族成员的结构和功能都高度保守。
Both the structures and the functions of aurora kinase family members are highly conserved in different model organisms.
极光激酶A催化结构域苏氨酸（288位）的磷酸化能够增强激酶的活性。
Phosphorylation of Aurora A at Thr288 in its catalytic domain increases kinase activity.
此外，极光激酶还参与了肿瘤形成的过程，已经发现一些靶向作用于极光的小分子具有显著的抑癌作用。
Moreover, aurora kinases also function in tumorigenesis. Some small molecules targeting to aurora kinases were found to have significant roles in tumor inhibition.
例如，所述化合物能够调节极光激酶，因此影响细胞循环和细胞增殖过程，用以治疗癌症和与癌症相关的疾病。
For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases.
极光激酶A（AIK）是一种调节细胞周期的丝氨酸/苏氨酸蛋白激酶，在多种肿瘤细胞系中过表达（1-3）。
Aurora A (AIK) is a cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines (1-3).
近年来，随着极光激酶相关研究的不断深入，人们逐渐认识到极光激酶在细胞有丝分裂以及肿瘤形成中的重要功能。
Due to the continuously deepening research on aurora kinases recently, the key functions of aurora kinases in cell mitosis and tumorigenesis have been gradually revealed.
近年来，随着极光激酶相关研究的不断深入，人们逐渐认识到极光激酶在细胞有丝分裂以及肿瘤形成中的重要功能。
Due to the continuously deepening research on aurora kinases recently, the key functions of aurora kinases in cell mitosis and tumorigenesis have been gradually revealed.
应用推荐