整合酶是病毒复制所需要的三种酶之一。
Integrase is one of the three enzymes of the irus that is required for iral replication.
目的：合理设计新的HIV-1整合酶抑制剂。
Objective: To rationally design new inhibitors of HIV-1 integrase.
结果55株临床菌株均为第1类整合酶基因阳性(100%)。
目的合成新型咖啡酸衍生物并测定其抑制HIV 1整合酶活性。
Aim To synthesize a series of new caffeic acid derivatives and test their HIV-1 integrase inhibitory activities.
实验方法与整合酶活性检测相似，只是整合酶需要和合成的多肽先进行预反应。
Inhibition experiment was performed as integrase activity assay expect that increasing concentrations of synthetic peptides were preincubated with the integrase.
结果：经PCR，酶切及测序方法鉴定，该腺病毒-整合酶嵌合系统构建成功。
Results:After being identified by PCR, restriction enzyme digestion and sequencing, the adeno-integrase hybrid system was successfully constructed.
由于HIV - 1整合酶的特殊功能，它已成为抗艾滋病药物设计工作的焦点之一。
Because of the special function of HIV-1 integrase, it has become one of focuses of anti-AIDS drug design.
HIV - 1整合酶(IN)通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中。
HIV-1 integrase (in) integrates viral DNA into host cells through two steps metal ions-dependent reactions.
整合酶抑制剂MK- 0518对以前没接受过抗病毒治疗病人，疗效就像目前最好的药物组合一样有效。
The integrase inhibitor MK-0518 worked as effectively as the best treatment available for individuals who have not previously received antiretroviral therapy.
给出了各个代表性体系的应用价值。旨在对HIV - 1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
三联苯曲菌素还没有被广泛的研究但已报道显示其有抗氧化的活性，做为一种植物生长抑制剂，也显示了弱的抗HIV整合酶的活性。
Terphenyllin has not been extensively studied but has been reported to exhibit anti-oxidative activity, acts as a plant growth inhibitor and shows weak activity against HIV integrase.
整合酶抑制剂；首次获准：2007年；抗病毒方式：整合酶抑制剂干预了整合酶酵素，艾滋病病毒正是通过整合酶酵素将自己的遗传物质传到人类细胞。
Integrase inhibitors 2007 integrase inhibitors interfere with the integrase enzyme, which HIV needs to insert its genetic material into human cells.
结果1类整合酶基因总阳性率为61.4%（113/184），2类整合酶基因总阳性率为4.3%（8/184），未检出3类整合酶基因阳性菌株。
Results Positive rates of class 1 integrase gene was 61.4%(113/184) in clinical isolates, class 2 integrase gene 4.3%(8/184) and class 3 integrase gene zero.
通过构建更精确的整合酶模型，这技术使未来未来搜寻新的药物分子成为可能，这些新药物分子将能通过稳定病毒蛋白酶的结构来抑制突变病毒的抗药性。
By producing a more accurate model of integrase, the research allows further searches for new drug molecules that will inhibit the mutant drug resistant forms of this enzyme, as well.
我们还整合了多种纤维素酶，这些酶可以把复杂的糖类转化成简单的糖类，并在同个细胞中进行发酵，制造出酒精。
We're also combining cellulases, the enzymes that break down complex sugars into simple sugars and fermentation in the same cell for producing ethanol.
结论：去整合蛋白和金属蛋白水解酶10和17的基因表达水平可能不是老龄人易发阿尔茨海默病的生物学基础。
CONCLUSION: The expression levels of ADAM 10 and ADAM 17 in hippocampus of old men may not be a part of biologic foundation of Alzheimer disease.
对部分经潮霉素筛选得到的再生植株进行了多次重复P CR检测，发现其中40 %以上的潮霉素抗性植株均表现出较强的阳性反应，初步证明几丁质酶基因已整合到油菜细胞核基因组中。
PCR test of the resistant plants indicated that 40% of the Hyg-resistant plants showed strong positive reaction, suggesting that chitinase gene had been integrated into the genome of rapeseed.
目的探讨血清去整合素-金属蛋白酶8 (ADAM8)水平对肺癌诊断及预后的价值。
Objective To investigate the value of serum ADAM8 level in diagnosis and prognosis of lung cancer.
考察了整合法固定漆树酶的最适条件。
The optimal condition of immobilization of laccase by chelating . method is investigated.
目的：观察大鼠海马内去整合蛋白和金属蛋白水解酶10和17基因表达的改变。
AIM: To investigate the change of gene expression of a disintegrin and metalloprotease (ADAM) 10 and ADAM 17 in hippocampus of rats.
结论外源基因(人组织蛋白酶k基因)已经整合到小鼠的染色体上，并且按孟德尔遗传定律中的分离定律进行遗传。
Conclusion the foreign gene (human Cathepsin K gene) has already integrated into mouse chromosome, and it can inherit in accordance with Mendelian inheritance.
结果转染后成骨细胞的基因组中整合有SV40T基因，碱性磷酸酶染色阳性细胞占95％以上；
Results Homologous integration of SV40T gene into RAE - 1 cell genome was positively detected by PCR. More than 95% cells were proved positively by alkaline phosphatase staining.
结果转染后成骨细胞的基因组中整合有SV40T基因，碱性磷酸酶染色阳性细胞占95％以上；
Results Homologous integration of SV40T gene into RAE - 1 cell genome was positively detected by PCR. More than 95% cells were proved positively by alkaline phosphatase staining.
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