他们对被称为“小神经胶质细胞”的这种免疫细胞尤其感兴趣,该细胞到处游走,清理细胞残骸。
They will be particularly interested in immune cells known as "microglia", which go around mopping up cellular debris.
博凯表示他们认为小神经胶质细胞可能合成一些对周围细胞有害的化学物质,这将导致阿尔茨海默病患者的病情加重。
Boche says they believe the microglia may produce chemicals that are harmful to surrounding cells and make Alzheimer's worse.
结论小胶质细胞与神经元,髓鞘存在密切接触,与星形胶质细胞之间存在交互性连接。
Conclusion The close contact exists in microglia and neurons, myelin, interactive connection was exist in microglia and astrocyte.
噬神经细胞现象,这个垂死的神经元被周围小胶质细胞包围。
This is an example of neuronophagia in which a dying neuron is surrounded by microglial cells.
自1891年首次描述小胶质细胞以来,其在中枢神经系统中作用越来越受到人们的重视。
Since first described in 1891, the role of central nervous system of the microglia is more and more been attention.
本文着重阐述小胶质细胞通过分泌这些效应分子引起神经功能损伤的机制,并对目前一些针对性治疗方法加以介绍。
In this article, we try to illustrate the mechanism how neural function is damaged by the microglial effector molecules, and introduce some current therapeutic approaches at the present time.
最新研究显示CD 200 - CD 200r通路是中枢神经系统内下调小胶质细胞活化的重要机制。
Latest studies have shown that CD200-CD200R pathway is an important mechanism which can reduced microglia activation in the central nervous system.
但是,在鱼藤酮诱导的多巴胺神经元变性过程中,小胶质细胞的作用尚未可知。
However, the role of microglia in rotenone-induced neurodegeneration has not been reported.
方法采用细胞株传代法培养PC12细胞及BV2细胞,分别替代神经元细胞和小胶质细胞;
Methods PC12 cells and BV2 cells, instead of neurons and microglia separately, were co-cultivated in transfer screen by cell passage method.
小胶质细胞是中枢神经系统常驻细胞,行使支持、营养、免疫监视等多种功能。
Microglia are resident immune cells of the CNS, which play the roles of sustaining, nourishing and immune surveillance.
因此,P 2x4受体和细胞内信号传导介质中的小胶质细胞是有希望的治疗靶点,为开发新的药物在神经性疼痛的管理。
Thus, P2X4 receptors and the intracellular signaling mediators in microglia are promising therapeutic targets for the development of novel pharmacological agents in the management of neuropathic pain.
因此,P 2x4受体和细胞内信号传导介质中的小胶质细胞是有希望的治疗靶点,为开发新的药物在神经性疼痛的管理。
Thus, P2X4 receptors and the intracellular signaling mediators in microglia are promising therapeutic targets for the development of novel pharmacological agents in the management of neuropathic pain.
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