因而喜树碱衍生物成为研究的热点。
Therefore, derivatives of camptothecin are becoming the focus of research.
喜树幽斑螟生物学特性的研究。
目的探讨羟基喜树碱对肠癌细胞的体外作用。
Objective: to explore the effect of hydroxy camptothecin on colorectal carcinoma cells in vitro.
喜树碱及其衍生物是一类具有抗癌活性的生物碱。
Camptothecin and its derivatives are alkaloids possessing anti tumor activities.
目的考查国内不同企业羟基喜树碱制剂的产品质量。
OBJECTIVE To investigate the quality of hydroxycamptothecine preparations manufactured by different companies.
目的观察羟基喜树碱对晚期胃肠道恶性肿瘤治疗效果。
Objective To observe the clinical effect of HCP t treatment on advanced gastroenteric tract tumors.
方法采用薄膜-超声法制备了9 -硝基喜树碱脂质体。
METHODS 9-nc liposome was prepared by film dispersion-sonication method.
用MTT法检测喜树碱对细胞增殖的抑制及有效浓度范围。
Inhibition on cells proliferation and effective concentrations of CPT are measured by MTT assay.
土壤干旱胁迫明显提高了喜树幼苗根、茎、叶中的喜树碱含量。
But soil drought stress increases CPT concentration in the leaves, stems and roots of the seedlings.
红膜下幼苗的喜树碱产量在第10天后与日光下幼苗差异不显著。
CPT yield under the red film treatment, however, is higher than that in sunlight only in Day 10, and no obvious difference is observed in other periods.
喜树碱与呋喃甲酸、吡啶甲酸、烟酸和异烟酸通过酯键进行偶联。
Camptothecin was coupled with 2-furonic acid, pyridinecarboxylic acid, niacin and isonicotinic acid through ester bond.
各处理对喜树幼苗内10 -羟基喜树碱含量的影响无规律可循。
No available rules can explain changes of 10-oh camptothecin content under all treatments.
通过对喜树叶与枝的成对比较分析，叶与枝的水溶性糖含量无显著差异。
The comparative analyses of Camptotheca acuminata Decne leaves and branches show that the difference between contents of soluble sugar in the leaves and branches is not very much.
通过紫外光谱和荧光光谱的方法研究了喜树碱与胰蛋白酶的体外相互作用。
Interaction between trypsin and CamptothecinThe interaction of trypsin with camptothecin (CPT) in vitro was studied by ultraviolet (UV) absorption spectral and fluorescence spectral methods.
喜树幼苗叶片次生代谢产物对光强变化的响应程度最大，根次之，茎最小。
The responses of the secondary metabolites in leaves of Camptotheca acuminate seedlings to different light intensity were the most obvious. Those in roots were second to them.
目的：研究10 -羟基喜树碱(HCPT)的内酯环形式与抗癌活性之间的关系。
AIM: to study the relationship between the lactone forms of 10-hydroxycamptothecin (HCPT) and their antitumor activities.
为了建立规范化的喜树栽培管理模式，本课题对喜树的部分重要营养特性进行研究。
In the present study, some nutritional characteristics of this plant species were investigated in order to improve their production technology.
目的：探讨人胃癌耐羟基喜树碱细胞株即SGC-7901/HCPT的耐药机制。
Objective:To investigate drug-resistance mechanism of the camptothecin(HCPT)-resistant stomach cancer cell line SGC-7901/HCPT.
目的研究10 羟基喜树碱（HCAM ）抗人肺癌细胞增殖、侵袭和诱导凋亡的作用。
Objective To study the effects of 10-hydroxycamptothecin (HCAM) on the inhibition of proliferation, anti-invasion and induction of apoptosis in highly metastasis lung cancer cells (PGCL3).
黄色遮光膜下生长的幼苗，虽然喜树碱含量稍高于正常，但与处理时间没有明显的相关关系。
The CPT concentration in leaves of seedlings under shading with yellow film is slightly higher than the normal, but it doesn't correlate with the treatment of time.
通过对喜树碱类药物研发过程的历史回顾，探讨其存在的哲学意义和对其它植物药研发的价值。
Through reviewing the process of developing camptothecin and its derivatives, to discuss its philosophy meanings and the value to development of other plant drugs.
结果悬浮培养细胞在M S培养基中细胞生长良好，细胞分散性和喜树碱积累优于在其他培养基中。
Results Suspension culture cells grew well in MS medium and cell homogeneity and camptothecin content were superior to those in other media.
目的：制备10 -羟基喜树碱的半固体脂质纳米粒(HCPT -SSLN)并考察其稳定性。
Objective: to prepare 10-hydroxycamptothecin-semisolid lipid nanoparticles (HCPT-SSLN) and investigate its stability.
目的研究草酸铂动脉介入联合羟基喜树碱(拓喜)腹腔灌注治疗直肠癌术后复发的近期疗效和毒副反应。
Objective: to investigate the efficacy and safety of Oxaliplatin intra-arterial infusion combined with Hydroxycampyothecin peritoneal infusion for treatment of relapse rectal cancer.
外源喜树碱处理的菌根共生体系中，植物与真菌的微管的荧光强度明显增强，可能表明了新微管的合成。
In the symbiosis system imposed by the exogenous Camptothecin, both the fluorescence of microtubules in plant and fungi were stronger than normal, maybe there were new microtubule synthesized.
目的：观察低剂量羟基喜树碱(HCPT)联合低剂量flp方案治疗晚期消化系肿瘤的疗效和毒副作用。
Objective: to observe the response and toxicity of combination with low-dose HCPT and low-dose FLP in patients with advanced digestive carcinoma.
结果通过一些特殊的传递方法与策略，可以解决喜树碱类药物所存在的溶解度、稳定性、毒性和不良反应等问题。
Result the problems of camptothecin such as solubility, stability and side effects could be solved by special delivery methods and strategies.
色氨酸合成酶(TSB)和色氨酸脱羧酶(TDC)是喜树碱合成过程中连接初生代谢和次生代谢过程的两个关键酶。
Tryptophan synthase (TSB) and tryptophan decarboxylase (TDC) are two key enzymes in camptothecin biosynthetic pathway as they links primary and secondary metabolism.
色氨酸合成酶(TSB)和色氨酸脱羧酶(TDC)是喜树碱合成过程中连接初生代谢和次生代谢过程的两个关键酶。
Tryptophan synthase (TSB) and tryptophan decarboxylase (TDC) are two key enzymes in camptothecin biosynthetic pathway as they links primary and secondary metabolism.
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