方法：选用组织相容性抗原复合体遗传背景不同的两种品系大鼠进行高危角膜移植。
METHODS: High risk corneal transplantation was performed using rats with different minor histocompatibility antigens.
目的：探讨FK- 5 0 6抑制高危角膜移植免疫排斥反应临床应用的可行性及有效性。
Objective: To evaluate the clinical probability and efficacy of FK-506 on suppressing cornea transplantation rejection.
角膜新生血管是角膜盲的主要原因，亦是角膜移植排斥反应的高危因素。
Corneal neovascularization (CNV) is one of the most causes of corneal blindness and the high-risk factor of corneal graft rejective reaction.
结论：与PK手术植片衰竭相关的高危因素包括角膜血管化、再次移植、无晶状体眼、人工晶状体眼、虹膜前或虹膜后黏连；
Conclusion:The risk factors for graft failure after PK were corneal vascularization, regraft, aphakia or pseudophakia, presence of anterior or posterior synechia.
以SD角膜新生血管化大鼠为受体，建立大鼠高危穿透性角膜移植动物模型。
SD rats with corneal vascularization were taken as recipients to establish animal model of high-risk penetrative corneal transplantation.
以SD角膜新生血管化大鼠为受体，建立大鼠高危穿透性角膜移植动物模型。
SD rats with corneal vascularization were taken as recipients to establish animal model of high-risk penetrative corneal transplantation.
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