本发明提供了比卡鲁胺片及制备工艺。
The invention provides a bicalutamide tablet and the related preparation process.
采用气相色谱法测定比卡鲁胺原料药中有机溶剂残留量。
The residual solvents in bicalutamide substance were determined by GC.
方法:以3-三氟甲基- 4-氰基苯胺和2- 甲基丙烯酰氯为起始原料经过酰化、 环氧化、取代和氧化四步反应合成比卡鲁胺。
Methods:Bicalutamide was prepared from 4-cyano-3-(trifluoromethyl) aniline and 2-methylacryloyl chloride by four steps: acylation, cyclization, substitution, and oxidization.
方法:以3-三氟甲基- 4-氰基苯胺和2- 甲基丙烯酰氯为起始原料经过酰化、 环氧化、取代和氧化四步反应合成比卡鲁胺。
Methods:Bicalutamide was prepared from 4-cyano-3-(trifluoromethyl) aniline and 2-methylacryloyl chloride by four steps: acylation, cyclization, substitution, and oxidization.
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