细胞到达靶器官、识别移植的异体抗原,启动一系列变化。
The T cell arrives at the target organ, the recognition transplant foreign body antigen, starts a series of changes.
ChristopherGarcia领衔的科研小组揭示了T细胞表面受体结构为何能双重识别,该现象也称为同种异体反应性。
Christopher Garcia have established how the structure of receptors on the surface of t cells enables this dual recognition, a phenomenon known as alloreactivity.
Garcia说,这些结构,与我们在其他实验中做的同样好,表现出T细胞受体对异体和自体MHC -蛋白复合物使用完全不同识别机制。
"These structures, as well as other experiments we did, showed that the T-cell receptor USES a completely different recognition mechanism for the foreign and self MHC-protein complex," said Garcia.
目的探讨间接同种异型识别在体外培养的同种异体表皮细胞移植排斥反应中的作用。
Objective To explore the effect of the indirect allo recognition on the rejection of epidermal cells.
因此Garcia说,人体T细胞受体的巨大潜能进化出对MHC分子的一种“记忆”,不但识别自体蛋白也识别异体蛋白。
Thus, said Garcia, the body's vast repertoire of T cell receptors has evolved a "memory" of the MHC molecules that recognize foreign as well as self proteins.
因此Garcia说,人体T细胞受体的巨大潜能进化出对MHC分子的一种“记忆”,不但识别自体蛋白也识别异体蛋白。
Thus, said Garcia, the body's vast repertoire of T cell receptors has evolved a "memory" of the MHC molecules that recognize foreign as well as self proteins.
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