这种多功能化合物是内皮抑制素,一种抑制血管生成,即身体内新血管生长的人体蛋白质。
The versatile compound is endostatin, a human protein that inhibits angiogenesis, the growth of new blood vessels in the body.
血管内皮抑制素能中断毛细血管的生长,从而饿死栓塞吗?
Could endostatin halt the growth of capillaries and starve the plaque?
打消了疑虑,国家癌症研究所今年下半年准许在癌症晚期的病人身上进行血管内皮抑制素临床实验。
gave the go-ahead for clinical trials of endostatin later this year on patients with advanced tumors.
目的探讨凝血酶对体外培养的原代大鼠脑微血管内皮细胞(bmvec)的损伤作用及凝血酶抑制剂水蛭素的保护作用。
AIM to investigate the apoptotic effect of thrombin on brain microvascular endothelial cell (BMVEC) of cultured rat, and the protective effect of hirudin, an inhibitor of thrombin.
结果:牛磺酸可明显减轻胃粘膜损伤,抑制内皮素释放,增加胃粘膜血流量,提高电位差。
Results: the taurine could significantly reduced gastric mucosal injury, inhibited the ET release, increase blood flow and potential difference of gastric mucosa.
内皮以抑素能抑制裸鼠皮下移植瘤的生长(P<0.05);
Endostatin significantly suppressed the growth of the implanted tumor in nude mice (P< 0. 05).
目的研究携带血管抑素K1-5基因的腺病毒载体对其对血管内皮细胞增殖的抑制作用。
Objective To investigate the suppression effects of a adenovirus vector containing angiostatin K1-5 gene to the proliferation and migration of vascular endothelial cells.
也抑制内源性内皮素转化酶、胶原酶和微生物来源的金属内蛋白酶活性。
Inhibits also the activity of Endothelin Converting Enzyme, collagenase and metallo-endoproteinases from many microorganisms. Does not inhibit serine, cysteine and aspartic proteases.
采用划线法和MTT法观察血管生成抑制素和反应停对淋巴管内皮细胞增殖和游走的影响。
Scraping line method and MTT were used to observe the effect of angiostatin and thalidomide on proliferation and migration of LEC.
结论葛根素可以缓解培养人脐静脉内皮细胞内钙超载,其作用机制可能与拮抗膜上电压依赖型钙通道和抑制内质网钙库释放有关。
Conclusion the mechanism of puerarin reducing the overload of calcium in HUVECs may be related with blocking both voltage-dependent calcium channels and the release of calcium pool in endoplasm.
结果提示,生长素可能部分通过拮抗血浆和血管组织局部的内皮素系统效应而产生抑制血管组织和血管平滑肌细胞钙化的作用。
Conclusion Our results indicated that ghrelin can significantly attenuate the calcification in aorta and VSMC partly through the antagonism with endothelin system in circulation and vascular tissues.
目的探讨反义vegf基因和内皮抑素基因联合转染在抑制肿瘤血管生成和肿瘤生长转移中的作用。
Objective to explore the co operative inhibitory effect of antisense VEGF gene and endostatin gene transfection on tumor angiogenesis, tumor growth and metastasis of lung cancer.
血管紧张素转换酶抑制剂(acei)治疗后冠心病组各型肱动脉内皮依赖性舒张功能与治疗前比较均有显著性改善,其中DD基因型改善最为明显。
After the therapy with angiotensin converting enzyme inhibitor (ACEI), the endothelium-dependent vasodilation function was improved in the coronary groups and especially for the DD group.
目的:内皮抑素是一种特异性血管内皮生长抑制因子,本研究目的在于探讨人内皮抑素对卵巢癌skov3细胞生长的抑制作用及其机制。
In this study, we aim to evaluate the inhibitory effect of endostatin on SKOV3 cell and to investigate the possible mechanism of the inhibition.
目的研究内皮素转换酶-1(ECE -1)反义RNA对人气道上皮细胞ECE -1表达的抑制作用。
Objective To explore the effects of endothelin converting enzyme-1 (ECE-1) antisense RNA on ECE-1 expression in human bronchial epithelial cell line(16HBE).
目的:探讨急性冠脉综合征患者应用阿托伐他汀调脂治疗后对血管内皮舒张功能、血浆纤溶酶原激活物抑制物1及血管内皮素1的影响。
Objective To study the effects of atorvastatin cholesterol-lowering therapy on vascular endothelial function and plasminogen activator inhibitor-1 in acute coronary syndromes.
内皮抑素是一种抗血管生成的抑制因子,它特异性地作用于新生微血管的内皮细胞,其水平与肿瘤血管生成有着明显的相关性。
Endostatin is a kind of angiogenesis inhibitor, specific effecting in the new microvascular endothelial cells. The level of endostatin and the angiogenesis of tumor have a close correlation.
其中用于提高耐力的主要有促红细胞生成素、血管内皮生长因子等,用于提高肌肉力量的有胰岛素样生长因子-I、肌肉生长抑制素、生长激素、机械生长因子等。
In those gene doping, EPO and VEGF are used to enhance the endurance performance; IGF-I, myostatin, GH and MGF are used to improve muscle strength.
从内皮细胞生长抑制素的来源、结构、药理作用、作用机制、制备方法、应用研究等诸方面,综述其最新研究进展。
The current progress in research on endostatin, including its source, structure, pharmacological action, mechanism of action, preparation method, application research and so on, was summarized.
内皮抑素是一种新的能强烈抑制血管形成的抑制因子,内皮抑素水平与肿瘤具有明显的相关性,其水平可以作为肿瘤的临床预后指标。
Endostatin is a new inhibitor factor which can intensively inhibit angiogenesis. The level of endostatin is significantly related to tumor, which can be a prognostic indicator of tumor.
结果发现,原花青素能够抑制一种称为内皮素- 1的蛋白质的产生,后者有收缩血管作用。
They found that procyanidins suppress production of a protein called endothelin-1 that constricts blood vessels.
通过建立荷人胃癌的裸鼠动物模型,分析基因转导后动物肿瘤细胞中内皮抑素的表达情况及对肿瘤的抑制作用。
Animal model of gastric cancer bearing nude mice were established to assay the expression of mouse endostatin and inhibition for tumor cell in vivo.
结论低分子肝素化内皮抑素可有效抑制角膜新生血管的生长,效果优于内皮抑素。
Conclusions LMWHES can effectively inhibit the growth of CNV and is superior to ES.
结论重组内皮抑素可有效抑制CNV生长,为临床防治CNV提供了一种新的方法。
Conclusion Recombinant endostain can effectively inhibit the growth of CNV, which provides a new method for the prevention and treatment of this condition.
结论重组内皮抑素可有效抑制CNV生长,为临床防治CNV提供了一种新的方法。
Conclusion Recombinant endostain can effectively inhibit the growth of CNV, which provides a new method for the prevention and treatment of this condition.
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