There is therefore a great deal of effort being put into finding drugs that increase p53 activity in such tumors.
因此研究者花费了大量的努力寻找可以激活如肿瘤内P53蛋白的药物。
As Thompson began to study the gene, he found that it was a target for a tumor suppressor gene called p53, which is a major controller of cell activity in prostate and other cancers.
当Thompson开始研究这个基因时，他发现RTVP - 1基因是肿瘤抑制基因p53的靶基因，p 53是前列腺癌及其他癌症细胞活性的最主要控制者。
Conclusion: P53 protein significantly inhibits telomerase activity in human keloid fibroblasts.
结论：P 53蛋白能够抑制人瘢痕疙瘩成纤维细胞端粒酶活性。
Researchers have identified a few compounds that restore p53 function, but until now, it has not been known whether such activity would actually reverse tumor growth in primary tumors.
尽管研究者已经发现一些化合物能够修复P53的功能，但直到现在，仍不能确定这些活性是否能够真正逆转原发肿瘤的生长。
In vivo phosphorylation at Ser315 has been observed following UV-irradiation, and a Ser315Ala mutant p53 has reduced activity as a transcription factor (17).
紫外辐射后第315位丝氨酸发生在体磷酸化已被观察到，而且Ser315Ala突变的p53能够减少其作为转录因子的活性（17）。
In vivo phosphorylation at Ser315 has been observed following UV-irradiation, and a Ser315Ala mutant p53 has reduced activity as a transcription factor (17).
紫外辐射后第315位丝氨酸发生在体磷酸化已被观察到，而且Ser315Ala突变的p53能够减少其作为转录因子的活性（17）。
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