When a person sustains a virologic response after completing treatment, this suggests that HCV infection has been cured.
当受试者完成治疗后病毒学应答仍在持续，说明丙型肝炎病毒感染已获治愈。
The best indicators of sustained virologic response are low pre-treatment serum HBV DNA titers and elevated alanine aminotransferase (ALT) levels.
持续性病毒学应答的最佳指标是较低的治疗前血清hbvDNA滴度和较高的谷丙转氨酶(ALT)水平。
The sustained virologic response rate was 79% and 80% in two studies, which was higher than the response rate of 50% with the standard of care with peginterferon plus ribavirin.
在两项试验中，持续的病毒学应答率为79%和80%，相比标准治疗方案，即长效干扰素联合利巴韦林的应答率50%更高。
CONCLUSIONS: IFN activates NK cells early after treatment is initiated. Their cytotoxic function, in particular, is strongly induced, which correlates to the virologic response.
结论：IFN在治疗初始就能激活NK细胞，其细胞毒性作用被强烈诱导，这与病毒学应答相关。
Sustained virologic response can result in decreased cirrhosis and complications of liver disease, decreased rates of liver cancer (hepatocellular carcinoma), and decreased mortality.
持续病毒学应答可以降低肝硬化和肝病并发症的发生，降低肝癌(肝细胞性癌)和死亡的发生率。
Conclusion it would be helpful to adjust the therapeutic regimen by testing YMDD mutations in patients who receive lamivudine therapy more than 6 months without complete virologic response.
结论对拉米夫定治疗6个月以上而没有达到病毒学完全应答的患者进行YMDD变异检测，有助于及时调整治疗方案。
Conclusion it would be helpful to adjust the therapeutic regimen by testing YMDD mutations in patients who receive lamivudine therapy more than 6 months without complete virologic response.
结论对拉米夫定治疗6个月以上而没有达到病毒学完全应答的患者进行YMDD变异检测，有助于及时调整治疗方案。
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