Tumor cellularity and mutant allele frequency were analyzed to identify tumor heterogeneity and mutant allele-specific imbalance.
通过分析肿瘤细胞的密度及等位基因突变的几率来确定肿瘤异质性和等位基因特异性突变的不平衡性。
Lower than expected mutant allele frequency indicated tumor heterogeneity, while higher than expected mutant allele frequency indicated mutant allele-specific imbalance.
等位基因突变几率预测肿瘤异质性方面低于预期，但等位基因突变几率预测等位基因特异性突变不平衡性方面则高于预期。
Objective To explore a novel methodology for tumor heterogeneity research, we reveal the feasibility of using co immunoprecipitation in the protein molecular mechanism of tumor heterogeneity.
目的探讨免疫共沉淀法在肿瘤异质性蛋白质分子机制研究中的可行性，为肿瘤异质性研究建立一种新的方法。
Objective:To investigate the heterogeneity of chemosensitivity in bladder cancer using an ATP-tumor chemosensitivity assay (ATP-TCA) and the feasibility of individual chemotherapy.
目的：探讨用ATP生物荧光肿瘤体外药敏检测技术（ATP-TCA）研究膀胱癌药敏的异质性和个体化疗的可行性。
Objective To investigate the heterogeneity of chemosensitivity in colorectal cancer using an ATP-tumor chemosensitivity assay (ATP-TCA) and the feasibility of individual chemotherapy.
目的探讨用atp生物荧光肿瘤体外药敏检测技术(atp -TCA)研究大肠癌药敏的异质性和个体化疗的可行性。
Objective:To investigate the heterogeneity of chemosensitivity in breast cancer using an ATP-tumor chemosensitivity assay (ATP-TCA) and the feasibility of individual chemotherapy.
目的：探讨用ATP生物荧光肿瘤体外药敏检测技术（ATP-TCA）研究乳腺癌药物敏感性的异质性以及个体化治疗的可行性。
The paper discussed the reasons for the enhanced metastatic capactity from metastatic heterogeneity of neoplasm, tumor cell-host interactions.
本文从肿瘤的异质性以及肿瘤与宿主相互作用的角度讨论了其肺转移提高的原因。
The heterogeneity of mouse ascitic tumor cells were studied.
应用小鼠腹水瘤细胞的克隆株研究异质性。
Conclusion CML consists of a group of diseases with high heterogeneity, and the prognoses of the patients mostly depend on the malignancy of the tumor.
结论慢性期CML是一组高度异质性疾病，肿瘤生物学恶性的高低决定了病人的预后。
Copy number analysis revealed intratumoral heterogeneity and evidence for divergent tumor evolution in malignant phyllodes tumors with and without heterologous differentiation.
拷贝数分析显示肿瘤具有异质性，具有异源性分化的恶性叶状肿瘤有不同的肿瘤演化。
Regional and genetic heterogeneity of HER2 gene amplification was determined in three different areas of each tumor by immunohistochemistry and silver in situ hybridization.
对每个肿瘤三个不同区域进行免疫组化和银原位杂交，以判定HER2基因扩增的区域异质性和遗传异质性。
Understanding tumor diversity has been a long-lasting and challenging question for researchers in the field of cancer heterogeneity or tumor evolution.
理解肿瘤多样化是肿瘤异质性和癌症进化的长期挑战的问题。
Background: Breast cancer is characterized by genetic heterogeneity, encompassing different tumor types with distinct biologic features and clinical behaviors.
背景：乳腺癌是一种异质性疾病，其临床表现相似，但生物学行为及预后却差异明显。
Background: Breast cancer is characterized by genetic heterogeneity, encompassing different tumor types with distinct biologic features and clinical behaviors.
背景：乳腺癌是一种异质性疾病，其临床表现相似，但生物学行为及预后却差异明显。
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