OBJECTIVE: To study the clinical pharmacokinetics and relative bioavailability of two kinds of tramadol hydrochloride sustained-released tablets.
目的：研究两种盐酸白马多缓释片的药代动力学及相对生物利用度。
Conclusion the dissolution rate of tramadol hydrochloride tablets from different manufacturers were remarkably different, dissolution measurement is needed for controlling the quality.
结论不同厂家生产的盐酸曲马多片的溶出度明显不一致，进行溶出度检查有助于控制质量。
METHODS Different particle size of tramadol hydrochloride, viscosity grades and the amount of HPMC, additive content and process were used to prepare tramadol hydrochloride sustained release tablets.
方法分别采用不同黏度与用量的羟丙甲纤维素(HPMC)，不同主药粒径与稀释剂，不同工艺制备盐酸曲马多缓释片。
METHODS Different particle size of tramadol hydrochloride, viscosity grades and the amount of HPMC, additive content and process were used to prepare tramadol hydrochloride sustained release tablets.
方法分别采用不同黏度与用量的羟丙甲纤维素(HPMC)，不同主药粒径与稀释剂，不同工艺制备盐酸曲马多缓释片。
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