Establish a method for the determination of quinapril and its active metabolite quinaprilat in human plasma.
建立一种方法测定人血浆中喹那普利及其代谢产物喹那普利拉的浓度。
Objective:To establish a SPE-HPLC method for the determination of quinapril and its active metabolite quinaprilat in human plasma and to evaluate their pharmacokinetics and relative bioavailability.
目的：建立SPE—HPLC法测定人血浆中喹那普利及其代谢产物喹那普利拉的浓度，以研究喹那普利及喹那普利拉在健康志愿者中的药代动力学和相对生物利用度。
Objective:To establish a SPE-HPLC method for the determination of quinapril and its active metabolite quinaprilat in human plasma and to evaluate their pharmacokinetics and relative bioavailability.
目的：建立SPE—HPLC法测定人血浆中喹那普利及其代谢产物喹那普利拉的浓度，以研究喹那普利及喹那普利拉在健康志愿者中的药代动力学和相对生物利用度。
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