Aim To synthesize meropenem trihydrate, a carbapenem antibiotic.
目的合成碳青霉烯类抗生素美罗培南。
Objective To evaluate the efficacy of meropenem in moderate to severe bacterial infection.
目的观察美罗培南治疗中、重度细菌感染的有效性。
OBJECTIVE To evaluate the efficacy and safety of meropenem on the treatment of hospital acquired infection.
目的评价美罗培南治疗医院感染的临床疗效和安全性。
Meropenem did not have complete bactericidal effect and more bacterial endotoxin could be released at lower drug concentration.
美洛培南杀菌作用不完全且诱导细菌呈纺垂体样改变，可能导致内毒素释放增加，影响临床严重感染的预后。
Conclusion: Meropenem is significantly effective and safe in the treatment of blood system diseases complicated with infections.
结论：美罗培南治疗血液系统疾病合并感染疗效明显而且安全性好。
AbstractObjectiveTo explore the effect of meropenem on lower respiratory infection in newborn infants with mechanical ventilation.
目的探讨美罗培南在治疗机械通气新生儿下呼吸道细菌感染中的疗效。
Objective:To evaluate the clinical effectiveness and safety of meropenem in the treatment of blood system diseases complicated with infections.
目的：评价美罗培南在治疗血液系统疾病合并感染时的疗效和安全性。
METHODS: The minimal inhibition concentration (MIC) of meropenem against 136 clinical isolates was determined with double AGAR dilution method.
方法采用琼脂二倍稀释法测定美洛培南对136株临床分离菌的最小抑菌浓度(mic)。
Meropenem is a carbapenem antibacterial agent that has antimicrobial activity against gram-negative, gram-positive and anaerobic micro-organisms.
美罗培南是一种对格兰氏阴性、格兰氏阳性和厌氧细菌有抗菌活性的抗菌药。
Object To evaluate the clinical effectiveness and safety of meropenem in the treatment of severe blood system diseases complicated with infections.
目的评价美罗培南治疗重症血液系统疾病合并感染时的临床疗效及安全性。
The susceptibility rate of meropenem and imipenem to ciprofloxacin was 100%, while that of Escherichia coli and Klebsiella spp to ciprofloxacin was only 12%.
肠杆菌科细菌对美罗培南和亚胺培南的敏感率最高（100%），而对环丙沙星的敏感率仅为12%左右；
The susceptibility rate of meropenem and imipenem to ciprofloxacin was 100%, while that of Escherichia coli and Klebsiella spp to ciprofloxacin was only 12%.
肠杆菌科细菌对美罗培南和亚胺培南的敏感率最高（100%），而对环丙沙星的敏感率仅为12%左右；
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