The researchers also found that cultured neurons with mutant LRRK2 enzymes showed reduced survival.
研究人员还发现被引人突变lrrk2蛋白的体外培养的神经元生存率下降。
Here we found that LRRK2 deficiency conferred enhanced susceptibility to experimental colitis in mice.
我们在本研究中发现，LRRK2缺乏能增加实验性小鼠结肠炎之易感性。
The pathology of PD caused by mutated LRRK2 also includes formation of abnormal deposits, or "inclusions," in the neurons.
由突变lrrk2引发PD的病理学表现也包括在神经元里形成非正常沉积物或者称为内含体。
Results: LRRK2 were widely expressed through out the mouse brain, but showed significant differences in different region of the brain.
结果：LRRK2蛋白在小鼠脑组织内广泛表达，但在不同的区域或神经核团显示出不同的表达差异。
They have pinpointed the malfunction of the protein made by mutant forms of the gene called LRRK2 and how it affects neurons, ultimately leading to their death.
他们通过这个称为LRRK2基因的突变形式精确的了解到该蛋白的非正常功能，以及它是如何影响神经元并最终导致细胞死亡。
The reason was that Mr Brin had recently discovered that he has inherited from his mother a mutation of a gene called LRRK2 that appears to predispose carriers to familial Parkinson’s.
因为布林先生最近发现，他从母亲那里遗传了一个变异的基因LRRK2。 研究显示，变异的LRRK2可能使得有家族患病史的携带者患帕金森氏症的几率增加。
Thus, our study defines a new step in the control of NFAT activation that involves an immunoregulatory function of LRRK2 and has important implications for inflammatory bowel disease.
因此，我们的研究定义了调控NFAT激活作用之新的一个步骤，其涉及到LRRK2的免疫调节功能并对炎症性肠道疾病具有重要的影响。
Thus, our study defines a new step in the control of NFAT activation that involves an immunoregulatory function of LRRK2 and has important implications for inflammatory bowel disease.
因此，我们的研究定义了调控NFAT激活作用之新的一个步骤，其涉及到LRRK2的免疫调节功能并对炎症性肠道疾病具有重要的影响。
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