Background: HLA haploidentical bone marrow is a potential source of doner for children for its availability.
背景：人类白细胞抗原(HLA)半相合造血干细胞移植由于供源广泛，在儿科具有广阔的应用前景。
BACKGROUND: Successful homing of haemopoietic stem cells is the key step for the success of haploidentical bone marrow transplantation.
背景：移植后造血干细胞的顺利归巢是单倍相合骨髓移植成功的关键。
Besides technological advances, choosing the most appropriate donor is also an important factor to overcome the HLA barriers in haploidentical HSCT.
为克服供受体h LA差异对半相合移植的不利影响，除改良移植技术之外，选择最为合适的供体也是决定手术成败的重要因素。
Objective to establish a murine model of haploidentical peripheral blood transplantation and evaluate the characteristics of hematopoietic and immunological recovery.
目的建立单倍体相合外周血移植小鼠模型，探讨移植后造血及免疫重建特性。
MHC haploidentical allogeneic bone marrow transplantation was performed in the experimental group and MHC mismatched bone marrow transplantation in the control group.
实验组进行主要组织相容性复合物单倍型相合的同种异基因骨髓移植，对照组进行主要组织相容性复合物完全不相合的骨髓移植。
Purpose: to establish a murine model of haploidentical umbilical cord blood transplantation and evaluate the characteristic of hematopoietic and immunological reconstitution.
目的：建立小鼠半相合脐血移植模型，探讨多位点不相合脐血移植后造血及免疫重建特性。
We tested the activity of our safety switch by introducing the gene into donor t cells given to enhance immune reconstitution in recipients of haploidentical stem-cell transplants.
我们将基因导入用于加强单倍同一性干细胞移植受者免疫重建的供体T细胞，以此对该安全开关的活性进行了检验。
Methods: In this pilot study, 58 patients, 33 with high-risk or advanced leukemia, were transplanted with cells from an HLA-haploidentical family donor with at least 1 of 6 loci mismatched.
方法：5 8例血液恶性肿瘤患者，33例为高危或难治复发白血病，接受了至少一个HLA位点不合的家庭供者造血干细胞移植。
Methods: In this pilot study, 58 patients, 33 with high-risk or advanced leukemia, were transplanted with cells from an HLA-haploidentical family donor with at least 1 of 6 loci mismatched.
方法：5 8例血液恶性肿瘤患者，33例为高危或难治复发白血病，接受了至少一个HLA位点不合的家庭供者造血干细胞移植。
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