Often the result of a new germline or somatic mutation.
通常源于种系的新突变或体细胞突变。
Finally I should say a word about germline gene therapy.
最后，我应当提一句生殖系基因疗法。
Defensive mechanisms based upon germline-encoded receptors constitute a system of innate immunity.
遗传而来的受体所建立的防御机制为先天性免疫系统。
We hypothesized that germline variation contributes to MPN predisposition and phenotypic pleiotropy.
我们推测种系变异可促进MPN易感及表型多向性。
Objective To explore germline mutation frequencies and features of mismatch repaired gene MSH6 in persons with different kinds of colorectal cancer.
目的了解错配修复基因MSH6在不同形式大肠癌人群中的种系突变频率及特征，提供真正的突变热点。
Now the two elite organisations have ruled that gene editing of the human "germline" - inherited DNA - should not be seen as a red line in medical research.
如今，这两家一流机构已经认定不应将对人类“生殖细胞”——遗传dna——进行基因编辑视为医学研究中的红线。
According to reports, ESC culture in vitro was more than two years and attained 450 serial passages. Embryonic germline ESC attained 70~80 passages at most.
据报道，ES细胞目前已有在体外培养两年，连续传代达450次以上，而胚胎生殖干细胞传代次数最多可达70~80次。
There are germline polymorphisms lying in all of the three genes that can cause significant decrease of enzymes expression and might have solid impact on genetic susceptibility of COPD.
以上三种基因均存在显著影响产物表达水平的多态现象，从而推测这些重要的多态改变能够影响中国人COPD的遗传易感性。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate into germline cysts.
作者表明从gsc或者其前体原始生殖系细胞(PGCs)去除翻译抑制物nan os将使两种细胞分化成生殖系包囊。
Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate into germline cysts.
作者表明从gsc或者其前体原始生殖系细胞(PGCs)去除翻译抑制物nan os将使两种细胞分化成生殖系包囊。
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