Fluticason propionate(1) in overall yield of 60.1% was synthesized from Flumethasone by oxidation, esterification, acylation, alcoholysis and fluoromethylation.
以双氟美松为原料，经氧化、酯化、酰化、醇解和氟甲基化反应制得氟替卡松丙酸酯（1），总收率60。
Fluticason propionate(1) in overall yield of 60.1% was synthesized from Flumethasone by oxidation, esterification, acylation, alcoholysis and fluoromethylation.
以双氟美松为原料，经氧化、酯化、酰化、醇解和氟甲基化反应制得氟替卡松丙酸酯（1），总收率60。
应用推荐