FHIT; gene transfer; apoptosis; hepatocarcinoma.
FHIT基因；基因转染；凋亡；肝癌。
FHIT gene was a new be identified as tumour suppressor gene recently.
FHIT基因是一个近年来发现的新的抑癌基因。
Results FHIT gene expressed in all of the chronic cervicitis tissue (100%).
结果FHIT在慢性宫颈炎组织中呈100%表达。
Objective: To evaluate the relationship between FHIT gene and gastrointestinal cancers.
目的：探讨FHIT基因与胃肠肿瘤的关系。
Objective To study the relationship between aberrant FHIT transcription and colon carcinoma.
目的研究脆性组氨酸三聚体（FHIT） 基因异常转录与结肠癌的相关性。
FHIT is an important tumor suppressor gene, in a variety of tumors expression was found missing.
FHIT是一种重要的抑癌基因，在多种肿瘤中被发现表达缺失。
Conlusion The human FHIT recombinant eukaryotic expression plasmid was constructed successfully.
结论成功构建了重组人FHIT真核表达质粒。
Conclusion the aberrant transcripts of FHIT gene maybe related with the development of gastric cancer.
结论FHIT基因的异常转录可能与胃癌的发生有关。
The FHIT protein deletion in HCC was higher than that in paratumor tissues and normal liver tissues (P<0.01).
正常肝组织中全部呈阳性表达，HCC组织中FHIT蛋白缺失率显著高于相应癌旁及正常肝组织（P<0.01）。
Methods: Expression of FHIT protEIn in breast carcinoma tissues of 62 cases was detected by SP immunohistochemistry.
方法：采用免疫组织化学sp法，检测62例乳腺癌组织中FHIT蛋白的表达情况。
Abnormalities in the FHIT gene its expression have been identified in a variety of human cancer cell lines and tumors.
越来越多的研究发现FHIT基因在大量的原发性肿瘤及细胞株中存在异常，该基因被认为是一个候选的抑癌基因。
The tumor suppressor gene FHIT is inactivated by genetic and epigenetic changes in the majority of common human cancers.
多数常见癌症中，肿瘤抑制基因FHIT的表达因受遗传或表观遗传因素的作用而受到抑制。
Conclusion FHIT gene expressing deletion was common in lung squamous carcinoma and was apparent correlative with smoking.
结论FHIT表达缺失是肺鳞癌的常见事件，而且与吸烟明显相关。
Methods Immunohistochemical method was used to detect the expressions of FHIT in 48 cases of OSCC and 26 normal oral mucosa.
方法：采用免疫组织化学方法检测48例oscc和26例正常口腔黏膜组织中FHIT的表达情况。
There exist hypermethylation, abnormal transcription of FHIT gene and down-regulation expression of FHIT protein in liver cancer.
肝癌中存在FHIT基因高甲基化、转录异常、FHIT蛋白表达下降。
We found a strong positive correlation between FHIT methylation in the plasma and the clinical stage and histological grade of the tumor.
随着患者临床分期和组织学分级的增加，FHIT基因甲基化的检出率也在逐渐的增加。
FHIT transcript abnormality preferentially occur in squamous cell carcinomas, and it might be the early molecular phenomenon of lung cancer.
FHIT基因异常主要发生在肺鳞癌中，且可能是肺癌发生的早期分子事件。
Objective: To investigate the expression characteristics of FHIT protEin in breast carcinomas and its relationship with clinicopathological parameters.
目的：探讨FHIT基因蛋白在乳腺癌中的表达特点及其与临床病理参数的关系。
To investigate the expression of apoptosis inhibitor gene FHIT in human glioma and study its clinical-pathological implication and clinical significance.
目的探讨人脑胶质瘤组织脆性组胺三联体(FH IT)的表达及其临床意义。
Objective To study the expression of fragile histidine triad (FHIT) in oral squamous cell carcinoma (OSCC), and discuss its role and significance in OSCC.
目的：检测抑癌基因脆性组氨酸三聚体(FHIT)基因在口腔鳞状细胞癌(OSCC)的表达情况，探讨其在OSCC发生过程中的作用及其意义。
The alternations of FHIT gene correlate with several clinic pathological indicators such as progression, invasion, relapse rate, and survival rate of liver cancer.
FHIT基因的改变与肝癌的演进、侵袭性、复发率和生存率等多项临床病理指标有关。
AIM: To analyze the relationship between lung cancer and length polymorphisms of microsatellite D3S1234 and D3S1300 located on fragile histidine triad (FHIT) gene.
目的：研究脆性组氨酸三联体(FHIT)基因微卫星D3S1234和D3S1300长度多态性与肺癌的关系。
Objective: to detect allelic deletion and mutation of FHIT gene in gastric cancer, and to analyze the role of the abnormalities in the carcinogenesis of gastric cancer.
目的：检测脆性组氨酸三联体基因在胃癌组织中等位基因缺失和突变情况，分析该异常在胃癌发生中的作用。
The loss of FHIT expression did not correlate with histological type, cell differentiation, clinical stage and metastasis, but was frequently observed in tobacco smokers.
FHIT基因失活与吸烟相关，但与组织学类型、分化程度、临床分期和转移无关。
Methods: Matched normal and cancerous tissues from 41 patients with colorectal cancer and 25 patients with colorectal adenoma were examined for FHIT expression using RT-PCR.
方法：采用逆转录巢式酶链免疫反应，对41例结直肠癌组织及其配对的癌旁正常组织和25例良性腺瘤的FHIT基因进行检测。
Conclusions: Transfecting the exogenous FHIT gene into gastric cancer cells can suppress the proliferation of tumor cells, and can also induce apoptosis and cell cycle arrest.
结论：向胃癌细胞中导入外源性FHIT基因可以抑制肿瘤细胞增殖，诱导细胞凋亡并引起细胞生长周期阻滞。
Conclusion FHIT gene may play a role in the regulation of cell proliferation of lung cancer, and the reduction in FHIT expression may be related to the pathogenesis of lung cancer.
结论FHIT基因可能参与肿瘤细胞增殖的调控，FHIT基因表达下降可能与肺癌的发生密切相关。
Conclusions FHIT and WWOX are candidate tumor suppressor genes. Detected coordinately with other (molecular) parameters, they can make the prognosis of therapy more accurate to predict.
结论FHIT和WWOX基因系重要的候选抑瘤基因，与其他预后指标的联合检测可望对患者的治疗预后作出更准确的预测。
The alternation of FHIT gene is an early and frequent event of liver cancer, and FHIT gene as a new molecular indicator of liver cancer can monitor the prognosis of liver cancer patients.
FHIT基因的改变在肝细胞癌中是早期频发的事件，可以成为肝癌患者预后一种新的分子指标。
The expression level of FHIT gene was closely related to histological classification, cancer cell differentiation, P TNM stages and lymph node involvement in lung cancer patients (P<0.05).
肺癌组织中FHIT基因表达水平降低与肺癌组织学类型、细胞分化程度，患者PTNM分期、淋巴结转移程度存在相关性（P< 0 .0 5） ；
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