The versatile compound is endostatin, a human protein that inhibits angiogenesis, the growth of new blood vessels in the body.
这种多功能化合物是内皮抑制素，一种抑制血管生成，即身体内新血管生长的人体蛋白质。
Could endostatin halt the growth of capillaries and starve the plaque?
血管内皮抑制素能中断毛细血管的生长，从而饿死栓塞吗？
The refolded endostatin was then purified by cation-exchange chromatography.
复性结束后用阳离子交换层析纯化。
Objective To observe the inhibitive effect of endostatin on human glioma cells.
目的观察内抑制素对人脑胶质瘤细胞增殖的影响。
Endostatin significantly suppressed the growth of the implanted tumor in nude mice (P< 0. 05).
内皮以抑素能抑制裸鼠皮下移植瘤的生长（P<0．05）；
gave the go-ahead for clinical trials of endostatin later this year on patients with advanced tumors.
打消了疑虑，国家癌症研究所今年下半年准许在癌症晚期的病人身上进行血管内皮抑制素临床实验。
In this review we summarized the characteristics of endostatin, its mechanism and applied to antitumor.
我们简要综述了内皮抑素的特性、作用机制，及其在抗肿瘤应用等方面的研究进展。
Objective: to study the inhibitory effects on gastric cancer by adenoviral transduction of mouse endostatin gene.
目的：研究腺病毒介导的鼠内皮抑素基因对胃癌的治疗作用。
Objective to investigate the effects of endostatin on patients of rheumatoid arthritis by intraarticular injection.
目的：探讨关节腔内注射生长抑素对类风湿性关节炎的疗效。
METHODS IL_3 signal sequence and human endostatin gene were amplified with PCR and spliced with overlap extension PCR.
方法用PCR方法扩增il_3信号肽序列和人内皮抑素基因，然后采用重叠延伸pcr拼接的方法将两者拼接和扩增。
Tumor growth was significantly inhibited by intramuscular or intratumoral endostatin gene administration which indicated…
结果表明，内抑素基因可在骨骼肌或肿瘤内表达，并显著抑制肿瘤生长。
In this study, we aim to evaluate the inhibitory effect of endostatin on SKOV3 cell and to investigate the possible mechanism of the inhibition.
目的：内皮抑素是一种特异性血管内皮生长抑制因子，本研究目的在于探讨人内皮抑素对卵巢癌skov3细胞生长的抑制作用及其机制。
Animal model of gastric cancer bearing nude mice were established to assay the expression of mouse endostatin and inhibition for tumor cell in vivo.
通过建立荷人胃癌的裸鼠动物模型，分析基因转导后动物肿瘤细胞中内皮抑素的表达情况及对肿瘤的抑制作用。
Objective To investigate the relation of endostatin (es) and the vascular formation in rectal cancer, and the effect of es on the invasion of rectal cancer.
目的研究内皮抑素(ES)与直肠癌血管形成的关系，探讨其在直肠癌侵袭行为中的作用。
Objective: To construct a replication-competent adenovirus vector carrying human endostatin gene, looking for an effective method for the therapy of colon cancer.
目的：构建携带内皮抑素基因的增殖型腺病毒载体，寻找结肠癌的有效治疗方法。
Objective to observe the altered gene expression of ECV304 cell after treated with endostatin (es) using cDNA microarray, and to investigate its molecular mechanism.
目的观察人脐静脉内皮细胞株(ECV304细胞)在内皮抑素(es)作用前后基因表达谱的变化，并探讨其作用的分子机制。
The sham group was normal control group (eight rats in each group). The expression of endostatin, VEGF and MVD in ischemic myocardium were observed by immunohistochemistry.
应用免疫组织化学染色方法，观察各组心肌梗死大鼠缺血心肌中内皮抑素、VEGF的表达和新生血管密度。
Methods Based on the reactive principle of molecular chaperone, we adopted an artificial molecular chaperone-assisted refolding method for recombinant endostatin refolding.
方法根据人工分子伴侣对重组蛋白质的复性机理，采用人工分子伴侣方法应用于重组内抑素的复性。
CONCLUSION: The mouse endostatin recombinant fusion protein expressed in E. coli by using thioredoxin fusion expression system is easy to be purified and possesses high activity.
结论：用硫氧还蛋白融合表达系统在大肠杆菌中表达的小鼠内皮抑素重组融合蛋白易纯化并具有高活性。
Objective to explore the co operative inhibitory effect of antisense VEGF gene and endostatin gene transfection on tumor angiogenesis, tumor growth and metastasis of lung cancer.
目的探讨反义vegf基因和内皮抑素基因联合转染在抑制肿瘤血管生成和肿瘤生长转移中的作用。
Objective: To investigate the variations of the serum endostatin level (se) and its relationship with spinal cord injury in the rats suffered from spinal ischemia-reperfusion lesions.
目的观察大鼠脊髓缺血再灌注后血清内皮抑素(SE)水平变化及其与脊髓损伤的关系。
Endostatin is a new inhibitor factor which can intensively inhibit angiogenesis. The level of endostatin is significantly related to tumor, which can be a prognostic indicator of tumor.
内皮抑素是一种新的能强烈抑制血管形成的抑制因子，内皮抑素水平与肿瘤具有明显的相关性，其水平可以作为肿瘤的临床预后指标。
The effect endostatin combined with TP seem to be superior to TP alone in some short term index for the treatment of postoperative NSCLC even though long-term survival is still anticipated.
重组人血管内皮抑素联合TP方案术后辅助治疗NSCLC较单纯化疗显示近期疗效上的优势、长期生存结果值得期待。
Methods Serum levels of endostatin were measured by an enzyme-linked immunosorbent assay (ELISA) in 44 patients with lung cancer, 20 patients with benign lung diseases and 20 normal persons.
方法应用酶联免疫吸附试验(ELISA法)，测定44例原发性肺癌、20例肺部良性疾病和20例正常人血清内皮抑素含量。
Endostatin is a kind of angiogenesis inhibitor, specific effecting in the new microvascular endothelial cells. The level of endostatin and the angiogenesis of tumor have a close correlation.
内皮抑素是一种抗血管生成的抑制因子，它特异性地作用于新生微血管的内皮细胞，其水平与肿瘤血管生成有着明显的相关性。
AIM: To study the expression of endostatin in ischemic myocardium of myocardial infarction (mi) rats in various periods and the correlation with VEGF expression and microvascular density (MVD).
目的：观察心肌梗死后大鼠不同时间缺血心肌中内皮抑素的表达及其与新生血管密度和血管内皮生长因子(VEGF)的关系。
The current progress in research on endostatin, including its source, structure, pharmacological action, mechanism of action, preparation method, application research and so on, was summarized.
从内皮细胞生长抑制素的来源、结构、药理作用、作用机制、制备方法、应用研究等诸方面，综述其最新研究进展。
The positive rate of expression about PCNA protein in the group without endostatin and the PBS group after the medication was not significantly different from that of before the medication(P>0.05);
PCNA在内皮抑素组治疗后的阳性表达率明显低于治疗前，其差异具有统计学意义（P<0.05）；
The positive rate of expression about PCNA protein in the group without endostatin and the PBS group after the medication was not significantly different from that of before the medication(P>0.05);
PCNA在内皮抑素组治疗后的阳性表达率明显低于治疗前，其差异具有统计学意义（P<0.05）；
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