某些新型N-酰化螺哌啶衍生物是人黑皮质素受体的配体和尤其是人黑皮质素-4受体（MC-4R）的选择性配体。
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R).
研究人员通过破坏下丘脑的黑皮质素受体4 (MC4R)或用药物使其关闭来阻断其反应，结果高密度脂蛋白含量同样会增加。
The researchers got the same high HDL levels results when they blocked the hypothalamus' melanocortin 4 receptor (MC4R) either by knocking it out or shutting it down with other chemicals.
研究人员通过破坏下丘脑的黑皮质素受体4 (MC4R)或用药物使其关闭来阻断其反应，结果高密度脂蛋白含量同样会增加。
The researchers got the same high HDL levels results when they blocked the hypothalamus' melanocortin 4 receptor (MC4R) either by knocking it out or shutting it down with other chemicals.
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