本发明涉及从阿德福韦制备阿德福韦酯二氧新戊酸双氧甲基酯的方法。
The invention relates to a method for preparing adefovir dipivoxil dual oxygen methyl pivalate from adefovir.
本论文是研究阿德福韦的合成工艺。
阿德福韦酯疗效发生缓慢，但耐药发生率低。
On the other hand, adefovir has a slow antiviral activity but with a lower rate of resistance.
阿德福韦治疗的持续时间为48周到240周。
The duration of adefovir therapy ranged from 48 to 240 weeks.
我认为有两个较为安全的选择：加用阿德福韦酯或改用替诺福韦。
I think the two safer options are to add adefovir with lamivudine or switch them to tenofovir.
治疗组给予加味五指毛桃汤口服，对照组给予阿德福韦酯胶囊口服。
Group was treated with oral soup flavored fingers peaches, control group was given capsules of oral adefovir dipivoxil.
目的 将难溶性药物阿德福韦酯制备成固体分散体，以增加体外溶出度。
Objective To prepare adefovir dipivoxil solid dispersion from poorly-soluble adefovir dipivoxil so as to improve its dissolution rate in vitro.
结论阿德福韦治疗后慢性乙型肝炎患者细胞免疫应答有一定程度的恢复。
Conclusion the cellular immune response of patients with hepatitis B was resumed in some extent after ADV therapy.
目的探讨国产阿德福韦酯治疗拉米夫定耐药慢性乙型肝炎的疗效及安全性。
ObjectiveTo evaluate the efficacy and safety of domestic adefovir dipivoxil in patients with hepatitis B resistant to lamivudine.
目的观察阿德福韦酯挽救治疗拉米夫定治疗后HBVDNA突破患者的疗效。
Objective To evaluate the efficacy of adefovir dipivoxil(ADV) on chronic hepatitis B(CHB) patients with HBV DNA breakthrough(>1.
目的建立阿德福韦酯对照品含量测定的非水滴定法，以解决无商品标准品的难题。
Objective To establish a non-aqueous titration method to determine adefovir dipivoxil standard, and prepare the authentic sample of the compound.
本文对检测阿德福韦双匹酯甲醇、乙腈和醋酸异丙酯残留量的方法学进行了研究。
This paper reports the text on the validation of determining procedures of these residual solvents in adefovir dipivoxil.
本发明涉及阿德福韦酯的制备方法，具体涉及到从阿德福韦制备阿德 福韦双特戊酸氧甲酯的制备方法。
The invention relates to a preparation method of adefovir dipivoxil, in particular to a method for preparing adefovir dipivoxil dual oxygen methyl pivalate from adefovir.
早期的研究已经显示，对慢性乙型肝炎e抗原阴性的患者进行48周阿德福韦治疗后，获得了临床上的改善。
Early research has shown that a 48-week course of adefovir provides clinical improvements in patients with HBeAg-negative chronic hepatitis B.
在制备阿德福韦酯的实验中，控制反应温度提高了反应产率，在减少了反应副产物的同时也使得产品提纯变得简便。
In the preparation of AD ester, we improve the yield by adjusting the reaction's temperature, make the byproduct fewer and also simplify the product's purification.
目的：建立一种快速、简单的测定大鼠血浆中阿德福韦酯水解产物阿德福韦单特戊酸甲基酯和阿德福韦的离子对反相高效液相色谱方法。
Objective:To establish a rapid and simple HPLC method for the determination of adefovir dipivoxil and its metabolites in the rat plasma in vitro.
相对于基线而言，纤维化得到改善患者的百分比与阿德福韦治疗的持续时间直接相关，从使用48周后的35%到使用240周后的71%。
The percentage of patients with improved fibrosis scores, relative to baseline, was directly related to the duration of adefovir therapy, ranging from 35% after 48 weeks to 71% after 240 weeks.
目前研究的焦点是确定使用阿德·福韦5年治疗的安全性和有效性。
The focus of the present study was to determine the safety and efficacy of adefovir treatment for up to 5 years.
的确有一些棘手的患者，即使联用拉米夫定和阿德·福韦酯治疗，仍然未出现充分的临床应答，或者在治疗过程中出现了肾毒性。
We do have a number of problem patients who have been on combination lamivudine and adefovir and have not had a sufficient clinical response to combined therapy or who develop nephrotoxicity.
《国际肝病》：然而在中国，恩替卡韦价格昂贵，替诺福韦尚未上市；因此，我们只能使用拉米夫定和阿德·福韦酯。
Hepatology Digest: Unfortunately in China, entecavir is very expensive and tenofovir is not yet licensed so we still use a lot of lamivudine and adefovir.
第52周之后，持续使用替比夫定者或者使用24周的阿德·福韦酯后改用替比夫定者的HBVDNA抑制效果较大。
After 52 weeks, HBV DNA suppression was greater in patients who had received continuous telbivudine or were switched to telbivudine after 24 weeks than in those who received continuous adefovir.
第52周之后，持续使用替比夫定者或者使用24周的阿德·福韦酯后改用替比夫定者的HBVDNA抑制效果较大。
After 52 weeks, HBV DNA suppression was greater in patients who had received continuous telbivudine or were switched to telbivudine after 24 weeks than in those who received continuous adefovir.
应用推荐