Pfizer的crizotinib专门攻击某种基因转录的蛋白,只有少于5%的非小细胞肺癌患者具有这种基因。 Roche的vemurafenib通过阻断基因B-RAF的变异体抵抗晚期黑色素瘤。
Pfizer's crizotinib attacks a protein encoded by a gene found in fewer than 5% of patients with non-small-cell lung cancer.
更重要的是我们已经证明,阻断这些基因中的一个,将会使癌细胞因缺乏重要的营养成分而挨饿——并减少肿瘤的大小和疾病的蔓延。
And importantly we've shown that blocking one of these genes will starve the cancer cells of vital nutrients - and reduce tumour size and spread of the disease.
这个研究小组发现,阻断一种基因可以使健康细胞对放疗产生免疫力,即使对于大剂量的放疗也同样有效。
The team have found that blocking the action of a gene seems to make healthy cells immune to even very large doses of radiation.
拉索尔教授运用了一项名为核糖核酸(RNA)干扰的新技术,仅在棉籽中建立了一个阻断棉子酚生长酶的基因序列。
Rathore used a new technique, called RNA interference, to construct a genetic sequence that blocked the gossypol-producing enzyme in the seeds only.
最有可能结合的药物是PLX4032,这种分子可阻断由B-RAF等位基因突变后产生的蛋白质的活动。
The most promising is PLX4032, a molecule which blocks the action of the protein produced by a specific mutation of a gene called B-RAF.
该小组随后发现了一个基因的改变,这一改变阻断了触角上探测这种物质的细胞之间的传感。
The team then discovered that a gene alteration stopped a sensory cell on the bugs' antennae from detecting the chemical.
哺乳动物细胞对双链RNA不识别意味着可用短发卡RNA来阻断信使RNA,从而使相应基因的信号无法传递。
This aversity to double-stranded RNA means short hairpins can be used to knock out the messengers, thus nullifying the signal from the underlying gene.
罗氏公司的vemurafenib通过阻断一种突变的基因b - raf攻击晚期黑色素瘤。
Roche's vemurafenib attacks advanced melanoma by blocking the mutated form of a gene, B-RAF.
曲妥珠单抗是一种人源化抗体,用于靶向和阻断her2的功能,而后者是由特异基因编码的一种蛋白,具有致癌潜能。
Trastuzumab is a humanised antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential.
不过,肺癌细胞则影响这些基因的表达,阻断化疗药物的作用。
But lung cancer cells sabotage the expression of these same genes to block assault from chemotherapy drugs.
由于腹泻和皮肤毒性限制了此类药物的应用,研究人员期望发现ABCG2基因特异性的突变从而能够阻断ABCG2蛋白的功能。
Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.
在任一点阻断这条通路,或者沉默与炎症小体形成相关的基因或者编码半胱天冬酶- 1的基因,都能导致细胞死亡数目增加。
Interrupting the pathway at any point, either by silencing the genes responsible for the inflammasome formation or the gene for caspase-1, resulted in increased cell death.
包括基因泰克和诺华制药在内的一些制药公司正在研究可以进入细胞内部并阻断VEGF的小分子抗癌药物。
But a number of drug companies including Genentech and Novartis AG are looking at small molecule cancer drugs that can get inside cells and block VEGF.
科学家们希望他们的发现可以最终研发出阻断该基因的药物,延缓或中止癌细胞的生长。
The scientists hope their findings will eventually lead to the creation of drugs to block the gene, which may slow down or stop the growth of cancer cells.
伦敦的科学家们发现了导致近视的基因,并有信心研发药物,制止眼睛的扭曲生长,阻断近视的发生。
Scientists based in London have identified a gene that causes myopia and are confident that drugs could be developed to halt the distorted growth of the eye that brings about the condition.
正在被讨论的该基因,其在正常情况下会增加一种天然记忆阻断蛋白水平。
The gene in question normally increases levels of a natural memory-blocking protein.
研究人员发现了新的小分子,这些小分子可能会在前列腺癌细胞将正常细胞转变为癌细胞过程中阻断癌细胞关闭正常基因的表达。
Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells.
方法通过鸡胚尿囊腔传代自普通级小鼠肺脏分离病毒,经血凝实验、血凝阻断实验和结构基因序列测定对分离得到的病毒进行鉴定;
MethodsThe virus was isolated from conventional mice lungs through chicken embryo passages and identified by haemoglutination test, haemoglutination blocking test and constitution genes sequencing.
但他又说它能鼓舞研究者们去继续从事作为阻断或者抑制艾滋病毒手段的基因治疗。
But he said it could inspire researchers to pursue gene therapy as a means to block or suppress HIV.
这些疗法能够阻断致癌基因的作用。
These treatments could block the effects of cancer-causing genes.
Fauci说:“它帮助证明了一个概念,即如果基因治疗能阻断CCR5的表达,那就可能会抑制病毒的复制能力。”
"It helps prove the concept that if somehow you can block the expression of CCR5, maybe by gene therapy, you might be able to inhibit the ability of the virus to replicate," Fauci said.
事实证明,SCC肿瘤细胞中缺失的这个基因能够能发出信号阻断肿瘤细胞增生。
This gene is missing in SCC tumor cells and, as it turns out, provides the signal for cells to stop multiplying.
这些化合物将会在有痴呆的基因鼠模型中进一步验证,来判断在动物模型中是否也存在类似的阻断效应。
These compounds will be tested in mice that have been genetically modified to have the characteristics of dementia to see if the compounds have similar inhibiting effects in an animal model.
SITR 1是一种组蛋白脱乙酰基酶,一种能够阻断来自调节基因的转录因子的蛋白质。
SITR1 is a histone deacetylase, a protein that blocks transcription factors from regulating genes.
迪肯认为,假如能够阻断这种基因的活动,研究人员就有可能阻止病情的进展,就算是已经全面发作的艾滋病病人也一样有用。
If its activity can be blocked, suggests Deacon, researchers might be able to hold the progression of disease at bay, even in people who have developed full-blown AIDS.
而且,红藻氨酸盐诱导的Gamma节律信号可以被RAGE基因缺失或抗体阻断的方式减弱。
Moreover, the kainate-induced gamma oscillations were attenuated by the genetic deletion or antibody blockade of RAGE in vivo.
而且,红藻氨酸盐诱导的Gamma节律信号可以被RAGE基因缺失或抗体阻断的方式减弱。
Moreover, the kainate-induced gamma oscillations were attenuated by the genetic deletion or antibody blockade of RAGE in vivo.
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