错配修复基因功能缺失时，细胞常会因基因突变聚集而表现为遗传不稳定。
When function defects of mismatch repair genes, Cell Showes Genomic instability because of the aggregation of mutation.
由于错配修复基因缺陷而导致的基因组不稳定，被认为是导致肿瘤发生的一条新途径。
The instability of genome which results from defect of MMR genes is thought as a new oncogenesis way.
目的了解错配修复基因MSH6在不同形式大肠癌人群中的种系突变频率及特征，提供真正的突变热点。
Objective To explore germline mutation frequencies and features of mismatch repaired gene MSH6 in persons with different kinds of colorectal cancer.
DNA错配修复系统可以识别并纠正DNA复制过程中出现的错误，保证基因组的稳定性和完整性。
DNA mismatch repair system could recognize and repair mistakes in process of DNA replication, guard stability and integrality of genome.
同源重组的后果，在不同等位基因之间的杂交使其中的一个等位基因被转换成了另一个等位基因。这是由错配修复引起的。
Consequence of homologous recombination, in which hybridization between different alleles causes one allele to be converted into the other. This occurs by mismatch repair.
背景对那些携带错配修复(MMR)基因突变且有林奇综合症的结直肠癌患者来说，手术方式是有争议的。
Background Surgical management of colon cancer for patients with Lynch syndrome who carry a mismatch repair (MMR) gene mutation is controversial.
背景对那些携带错配修复(MMR)基因突变且有林奇综合症的结直肠癌患者来说，手术方式是有争议的。
Background Surgical management of colon cancer for patients with Lynch syndrome who carry a mismatch repair (MMR) gene mutation is controversial.
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