在小鼠模型中，GNA11突变诱导了自发转移性肿瘤，激活了丝裂原活化蛋白激酶途径。
Mutations in GNA11 induced spontaneously metastasizing tumors in a mouse model and activated the mitogen-activated protein kinase pathway.
因此，本研究的目的是调查金雀异黄素，一种蛋白质酪氨酸激酶抑制剂，对有急性或慢性糖尿病炎症小鼠（诱导脲佐菌素）的影响。
Therefore, the aim of this study is to investigate the effects of genistein, a protein tyrosine kinase inhibitor, on acute and chronic inflammation in diabetic mice (induced by streptozotocin).
低氧条件会直接诱导丙酮酸脱氢酶激酶1 (PDHK1)的表达，它的表达会抑制pdh的活性和TCA循环，从而抑制了随后的代谢通路(4)。
Hypoxia can directly induce pyruvate dehydrogenase kinase 1 (PDHK1) expression, which results in inactivation of PDH and the TCA cycle and subsequent suppression of metabolism (4).
这可能解释以前的研究数据发现抑制酪氨酸激酶活性不足以诱导细胞死亡，或抑制EGFR的所有功能。
This may help to explain previous data indicating that inhibition of EGFR kinase activity is not sufficient to induce cell death, or to negate all of the functions of EGFR.
目的探讨细胞外信号调节激酶（ERK）在NGF诱导的PC12细胞分化中的作用机制。
Objective To decide whether the extracellular signal-regulated kinase (ERK) play a crucial role in PC12 differentiation induced by nerve-growth factor (NGF).
结果表明，外源乙烯能诱导草莓果实乙烯大量合成，比对照（未经任何处理）提高420%和73%，抑制NAD激酶活性约20%和40%，对NADP磷酸酶影响不明显。
The results showed that exogenous ethylene could increase ethylene production by 420% and 73%, reduce the activity of NAD kinase by 20% and 40% and had no obvious effects on NADP phosphatase activity.
目的：观察模拟失重条件下由骨形态发生蛋白2诱导的ROS17/2.8细胞中MEK1激酶活性的变化。
OBJECTIVE: To investigate the effects of simulated weightlessness on the activity of MEK1 induced by BMP-2 in ROS17/2.8 cells.
以药物诱导的方法建立了大鼠实验性甲亢模型，并对该模型心肌切片进行了免疫组化染色，检测肌酸激酶。
The rat model of experimental hyperthyroidism induced by the drug was built and the myocardium creatine kinase changes were analysized by immunohistochemical staining method.
在水稻胆碱激酶的启动子区发现有干旱应激元件DRE2，暗示该基因可能受脱水诱导。
A responsive element, DRE2 was found in the promoter region of the gene, which indicated that the choline kinase gene expression might be inducible by the dehydration.
目的：探讨辛伐他汀对高脂诱导的大鼠肾组织整合素连接激酶(ILK)的表达及其对肾小管间质损害的影响。
AIM: To explore the effect of simvastatin on expression of integrin-linked kinase (ILK) and the injury of renal tubulointerstitium in the rats induced by high fat diet.
目的：探讨细胞外信号调解激酶（ERK）对蟾蜍灵诱导白血病细胞凋亡的影响。
Objective: To explore the effect of extracellular signal-regulated kinase(ERK) on the apoptosis induced by bufalin in K562 cells.
结论：在苦参碱诱导K562细胞分化的过程中，涉及到蛋白酪氨酸激酶的活性改变。
Conclusions: the change of protein tyrosine kinase activity is involved in the differentiation of K562 cells induced by matrine.
结论扭转蛋白A可能是膜相关蛋白，细胞氧化应激中扭转蛋白A表达上调和重分布变化不是由佛波酯诱导的蛋白激酶C活化途径来实现的。
The up-regulation and redistribution of TorsinA is not caused by the pathway of the PMA activating PKC after cells insulted by oxidative stress.
JANEX- 1具有良好的抗白血病活性，它可诱导酪氨酸蛋白激酶过度表达的淋巴性白血病细胞和髓性白血病细胞凋亡。
JANEX-1 exhibits significant anti-leukemia activity, which could induce apoptosis in human lymphoblastic as well as myeloblastic leukemia cells with over-expressed tyrosine protein kinase.
本文对丁酸钠诱导分化的人白血病细胞株k- 562细胞的胰岛素受体酪氨酸蛋白激酶性及细胞内源性底物进行了研究。
In this paper, the tyrosine protein kinase activity of insulin receptor and its endogenous substrates were investigated on the human leukemia cell line K-562 differentiated by sodium butyrate.
经磷酸化活化的丝裂原活化蛋白激酶，可参与多种细胞生命活动，如调节基因转录，诱导细胞凋亡、调节细胞周期等。
The MAPK which activated through phosphorylation involve several cell life activities, just like the control gene transcription, induce cell death, regulate cell circle and so on.
目的：研究冬凌草甲素诱导人组织淋巴瘤u 937细胞凋亡的机制及ERK激酶在凋亡过程中的作用。
Objective: to study the mechanisms of oridonin-induced U937 cell apoptosis, and to examine the role of ERK MAPK.
目的：构建人血清及糖皮质激素诱导型蛋白激酶（SGK1）超表达载体质粒，为SGK1的体外研究提供有效的工具。
Objective:To construct plasmid with overexpressed human SGK1 to provide a useful tool for its studies in vitro.
目的：对比吴茱萸碱与化疗药物对A375 - S2细胞的细胞毒活性，并且研究PKC及ERK激酶在吴茱萸碱诱导a 375 -S2细胞死亡中的作用。
AIM: to compare the cytotoxic effect of evodiamine with chemotherapy drugs on A375-S2 cells, and to examine the relationship between the effects of PKC and ERK on evodiamine-induced cell death.
目的：对比吴茱萸碱与化疗药物对A375 - S2细胞的细胞毒活性，并且研究PKC及ERK激酶在吴茱萸碱诱导a 375 -S2细胞死亡中的作用。
AIM: to compare the cytotoxic effect of evodiamine with chemotherapy drugs on A375-S2 cells, and to examine the relationship between the effects of PKC and ERK on evodiamine-induced cell death.
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