目的研究表皮细胞生长因子受体在胃癌表达的临床意义。
Objective To study the clinical meaning of EGFR in gastric carcinoma.
许多种类的肿瘤可产生比普通细胞高得多的表皮生长因子受体,影响之一就是刺激了肿瘤细胞的扩散。
Many types of tumour produce far more EGFR than normal cells do, and one effect of that is to stimulate the proliferation of tumour cells.
例如,艾比特思和名为表皮生长因子受体(EGFR)的细胞表面蛋白的结合。
Erbitux, for example, binds to a cell-surface protein called epidermal growth-factor receptor (EGFR).
表皮生长因子受体通常促进细胞的生长发育,一旦发生基因变异,会使细胞不受控制地生长。细胞不受控制地生长,这正是癌症的特征。
EGFR normally promotes cell growth and development, and when mutated, allows the uncontrolled growth of cells that is the hallmark of cancer.
十多年前就取得了重大进展,一个加州的生物科技公司Genentech(中文名:基因泰克)发行了一种药物,这种药物攻击蛋白质HER2(中文名:人表皮生长因子受体- 2)含量过多的乳腺癌细胞。
A breakthrough came more than a decade ago when Genentech, a Californian biotech firm, launched a drug that attacks breast-cancer cells with too much of a certain protein, HER2.
中国的非小细胞肺癌病人中吉非替尼敏感的表皮生长因子受体酪氨酸激酶区域的突变。
Gefitinib-sensitive mutations of the epidermal growth factor receptor tyrosine kinase domain in chinese patients with non-small cell lung cancer.
非小细胞肺癌病人的表皮生长因子受体基因突变的临床病理意义。
Clinicopathologic Significance of the Mutations of the Epidermal Growth Factor Receptor Gene in Patients with Non-Small Cell Lung Cancer.
目的:研究表皮生长因子受体和增殖细胞核抗原在胃肿瘤中的表达及其临床意义。
Objective: To study the expression of EGFR and PCNA protein in human gastric neoplasm and its clinical significance.
表皮生长因子受体(EGFR)在人类肝细胞广泛表达,表皮生长因子可能是肝细胞生长中必须的有丝分裂原。
Epidermal growth factor receptor (EGFR) is frequently expressed in human hepatoma cells, and EGF may be one of the mitogens that are needed for the growth of hepatoma cells.
目的研究抑制素、表皮生长因子受体在人卵巢颗粒细胞瘤中的表达及临床意义。
Objective To investigate the expression of inhibin, epidermal growth factor receptor in human ovarian granulosa cell tumor and their clinical significance.
目的探讨表皮生长因子受体与细胞增殖、转化的关系。
Objective to explore the relationship between epidermal growth factor receptor (EGFR) and cell proliferation and transformation.
目的探讨表皮生长因子受体反义重组腺病毒联合放射线对乳腺癌细胞的作用。
Objective to investigate the effects of a recombinant antisense adenovirus for epidermal growth factor receptor combined with irradiation on breast cancer cells.
结论:表皮生长因子受体抑制剂ag1487可对舌鳞癌细胞产生明显的增殖抑制作用。
Conclusion: Epidermal growth factor receptor inhibitor AG1487 may retard cell cycle, and then inhibit the proliferation of tumor cells.
目的:了解表皮生长因子受体抑制剂AG1487对舌鳞癌细胞的抑制增殖作用。
Objective:To investigate the inhibitory effect of epidermal growth factor receptor inhibitor AG1487 on the proliferation of tongue cancer cells.
另外,表面半乳糖基转移酶通过调节表皮生长因子受体信号传导能力向胞内传递生长抑制信号,在细胞增殖控制中起重要作用。
Surface GalTase also delivers a growth inhibitory signal by modulating the ability of the EGF receptor to transduce EGF dependent signals, and plays an important role during cell growth.
目的探讨中国人非小细胞肺癌表皮生长因子受体(EGFR)第18、19、21外显子基因突变状态。
Objective to study the mutation patterns of epithelial growth factor receptor (EGFR) exon 18, 19 and 21 in Chinese non-small-cell lung cancers (NSCLC).
目的克隆人表皮生长因子受体(HER2)基因,建立共表达HER2基因和雌激素受体(ER)基因的MCF-7细胞模型。
Objective To clone human epidermal growth factor receptor (HER2) gene and establish a MCF-7 cell line with stable co-expression of HER2 and estrogen receptor (ER).
免疫细胞化学染色法检测表皮生长因子受体(EGFR)的表达;
The immunocytochemical stain and image analysis were applied to measure the expression of EGFR protein.
这是FDA批准的首个能够检测非小细胞肺癌患者表皮生长因子受体(EGFR)基因突变的、以血液为基础的基因检测试剂盒。
This is the first FDA-approved, blood-based genetic test that can detect epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer patients.
目的研究表皮生长因子受体在妊娠滋养细胞疾病的表达,探讨EGFR对预测葡萄胎恶变的价值。
Results Stain for EGFR was detected in all cell types of trophoblasts in GTD and normal chorion villi.
常用的受体有去唾液酸糖蛋白受体、胰岛素受体、血管内皮细胞生长因子受体、转铁蛋白受体、甘露糖受体、表皮生长因子受体、叶酸受体等。
Asialoglycoprotein receptor, transferrin receptor and receptors for lactoferrin, insulin, epidermal growth factor, folic acid and mannose have been used in receptor-mediated gene delivery.
最近一项使用表皮生长因子受体抑制剂的临床试验发现,患者的肿瘤细胞表达磷酸化或化学转化水平很高- Akt对这种疗法没有反应“Kwatra博士说。”
A recent clinical trial using an EGFR inhibitor found that patients whose tumors expressed high levels of phosphorylated - or chemically altered - Akt did not respond to treatment, Kwatra said.
其中,我们对于发生表皮生长因子受体(EGFR)突变和间变淋巴瘤激酶(ALK)重排的非小细胞肺癌患者的治疗取得了显著的进展。
We have made significant progress in the treatment of patients with mutations in the Epidermal Growth Factor Receptor (EGFR) and rearrangements involving anaplastic lymphoma kinase (ALK).
目的:探讨表皮生长因子受体(EGFR)基因酪氨酸激酶域体细胞在肺腺癌患者中突变的相关因素。
Objective: to study Somatic mutation of the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR gene) in lung adenocarcinoma patients.
目的:比较表皮生长因子受体(EGFR)在肝细胞癌及胆管细胞癌中表达的差异。
Purpose to explore the difference in the expression of epidermal growth factor receptor (EGFR) between hepatocellular carcinoma and cholangiocarcinoma.
目的探讨外周血表皮生长因子受体(EGFR)基因突变在非小细胞肺癌(NSCLC)吉非替尼治疗适宜患者筛选中的价值。
Objective to evaluate the clinical significance of epidermal growth factor receptor EGFR mutations in the treatment of non-small cell lung cancer NSCLC.
应用受体的放射配基结合分析法测定出甜菜碱对大鼠肝细胞膜表皮生长因子受体(EGF)及其酪氨酸蛋白激酶(TPK)有显著的结合抑制作用。
Using radioligand of binding assay of receptors determinates that betaine can inhibit the binding of EGF receptor with EGF and affect the TPK activity conspicuously.
应用受体的放射配基结合分析法测定出甜菜碱对大鼠肝细胞膜表皮生长因子受体(EGF)及其酪氨酸蛋白激酶(TPK)有显著的结合抑制作用。
Using radioligand of binding assay of receptors determinates that betaine can inhibit the binding of EGF receptor with EGF and affect the TPK activity conspicuously.
应用推荐