在大鼠的中脑切片中利用盐或单剂量的可卡因进行处理并不能在腹侧被盖区诱发ltp的产生,只有在利用荷包牡丹碱或苦味毒减弱gaba(氨基丁酸)介导的抑制作用时才可以观察到LTP的出现。
In midbrain slices from rats treated with saline or a single dose of cocaine, LTP could not be induced in VTA dopamine neurons unless GABA-mediated inhibition was reduced by bicuculline or picrotoxin.
荷包牡丹的传说:古时,在洛阳城东南 200来里路,有个州名叫汝州,州的西边有个小镇,名叫庙下。
Common bleedingheart's fable: The ancient times, south the Luoyang east end 200 mile road, have state named Ruzhou, the state west side have a small town, under named temple.
结果:GABAA受体拮抗剂荷包牡丹碱能逆转GABA摄取抑制剂3-哌啶甲酸引起的血压升高,GABAB受体拮抗剂CGP 35348则不能;
Results: GABA uptake inhibitor nipecotic acid-induced increase of MAP was blocked by GABAA receptor antagonist bicuculline, but not by GABAB antagonist CGP 35348;
结果:GABAA受体拮抗剂荷包牡丹碱能逆转GABA摄取抑制剂3-哌啶甲酸引起的血压升高,GABAB受体拮抗剂CGP 35348则不能;
Results: GABA uptake inhibitor nipecotic acid-induced increase of MAP was blocked by GABAA receptor antagonist bicuculline, but not by GABAB antagonist CGP 35348;
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