它还可能与其它药物相互作用,特别是心血管一类药物,例如ace抑制剂、受体阻滞剂和保钾利尿剂。
It can also interact with other medications, especially certain types of cardiovascular medications such as ACE inhibitors, receptor blockers and potassium-sparing diuretics.
但是近期的报道已经表明两种药物之间有潜在危险的相互作用,由此质子泵抑制剂降低抗血小板药物的实际效果。
But recent reports had suggested that there might be a potentially dangerous interaction between the two drug classes whereby PPIs reduce the actual effectiveness of antiplatelet agents.
药物相互作用的风险也会提高,因为两种药物都会抑制CYP34 A代谢途径,可能增加了依赖该代谢途径降解的药物的水平。
There's also an increased risk of drug-drug interactions, as both new agents inhibit the common CYP34A metabolic pathway, potentially increasing levels of other drugs metabolized that way.
目前确定候选药物出现此类相互作用可能性的主要方法是通过体外CYP450诱导和抑制潜能的快速筛选。
A rapid in vitro assessment of CYP450 induction and inhibition is a part of the current paradigms for identifying drug substances likely to be metabolized via such interactions.
而且CYP2D6能被多种药物竞争性抑制和诱导,药物联用时易产生相互作用。
Meanwhile, many drugs can influence the activity of CYP2D6 by competitive inhibition or induction, which is easy to cause interaction in coadministration.
还可能与其他药物相互作用,尤其是心血管药物,例如ace抑制剂,受体阻断剂和保钾利尿药。
It can also interact with other medications, especially certain types of cardiovascular medications such as ACE inhibitors, receptor blockers and potassium-sparing diuretics.
认识药物代谢的酶学基础,了解药酶的常见底物、诱导剂和抑制剂,合理选用同类药品,能避免有害药物代谢性相互作用的发生。
The adverse drug interactions can be avoided by knowing the enzymology basis of drug metabolism, common substrates, inductors, inhibitors involved and using the same kind of drugs rationally.
结论CYP1A是介导肉桂酸代谢转化的主要酶系,肉桂酸与抑制或诱导CYP1A酶的药物合用可能存在相互作用。
CONCLUSION CYP1A is the major enzyme in metabolism of cinnamic acid. The medicine, which have inducible and inhibitory effects on CYP1A, may have interaction with cinnamic acid.
结论CYP1A是介导肉桂酸代谢转化的主要酶系,肉桂酸与抑制或诱导CYP1A酶的药物合用可能存在相互作用。
CONCLUSION CYP1A is the major enzyme in metabolism of cinnamic acid. The medicine, which have inducible and inhibitory effects on CYP1A, may have interaction with cinnamic acid.
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