目的研究单味中药精制颗粒剂在临床应用的药效物质基础。
OBJECTIVE To study the medicinal material base for clinical application of the refined granules of single traditional Chinese herb.
但是，由于其药效物质基础不清楚，使质量控制上存在一定的问题。
However, because of the indistinctness of its effective substances, the quality control has some problems.
还应用HPLC-MS／MS研究不同组分提取物中的成分，在一定程度上阐明了药效物质基础。
The extracts of effective compounds were investigated by HPLC-MS/MS. To some extent, the effective substances of prescription compatibility were clarified.
结论总生物碱与总黄酮是五脉绿绒蒿抗炎、镇痛作用的共同药效物质基础，但总生物碱的镇痛作用明显优于总黄酮。
Conclusion total alkaloids and total flavonoids from MQR were all pharmacodynamic substance foundation, but analgesia effect of total alkaloids outweighed total flavonoids obviously.
结论可利用正交实验数据对BP网络进行训练，利用训练好的网络对中药药效物质基础的超临界萃取结果进行预测。
ConclusionOrthogonal experimental results could be used to training BP-NN and the trained BP-NN could forecast the extraction results of active components in Chinese herb medicines.
利用该方法已完成了茵陈蒿汤、越桔等中药的系统的血清药物化学研究工作，分析确定了其药效物质基础及药代动力学特性。
The new method is named Serum Pharmacochemistry Method of Trditional Chinese Medicine, by which, systematic studies on serum pharmacochemistry of such Chinese …
结果：确定吴茱萸汤的药效物质基础主要为产生X4，X9，X10和X12号色谱峰中的化学成分（已确认X9为吴茱萸次碱）。
RESULTS: The material basis of the Wuzhuyu decoction was found to be produced chiefly by the chemical constituents contained in No. X4, X9 (rutaecarpine), X10 and X12 chromatographic peaks.
提出中药药效物质组学研究策略，以实现中药药效物质基础与作用机理研究的一体化，进而从深层次揭示和全面控制中药的内在质量。
A new strategy with metabonomics is put forward to achieve integral study on therapeutic basis matter and action mechanism of TCM, and to reveal and control the comprehensive quality of TCM.
提出中药药效物质组学研究策略，以实现中药药效物质基础与作用机理研究的一体化，进而从深层次揭示和全面控制中药的内在质量。
A new strategy with metabonomics is put forward to achieve integral study on therapeutic basis matter and action mechanism of TCM, and to reveal and control the comprehensive quality of TCM.
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