调节性T细胞介导的免疫调节是自身耐受的重要机制之一。
Immunoregulation mediated by regulatory t cell is one of the most important mechanisms to maintain self tolerance.
目的探讨胸腺异位基因表达与自身耐受及自身免疫病的相互关系。
Objective To detect the relationship between the promiscuous gene expression in thymus and the diseases of self-tolerance and self-reaction.
若自身耐受因某些原因遭到破坏或中止时，就可能发生自身免疫反应或自身免疫病。
If the self tolerance is broken or blocked by some reasons, autoimmunity and some diseases might occur.
凭借个体免疫系统忽略自身组织同时全面防护外界感染，从而恢复细胞的自身耐受性。
The outcome is to reinstate self-tolerance whereby an individual's immune system ignores its own tissues while remaining fully armed to protect against infection.
近年来，调节性T细胞在自身耐受和抑制同种异体排斥反应中的作用受到越来越多的重视。
Recently, accumulating evidences have shown that regulatory t cells play a key role both in maintenance of self tolerance and tolerance to allograft.
小剂量口服自身抗原诱导免疫耐受可有效地抑制EAE和MS，这已被诸多研究所证实，但其机制尚不清楚。
Oral tolerance by feeding autoantigens is an effective method to prevent EAE and to treat MS, which mechanism has not been made very clear.
这些数据提示，疾病共同的生物学机制，比如有关自身免疫的组织损伤和对食物中抗原的不耐受，可能这两种疾病的共同病因。
These data suggest that common biologic mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiologic features of both diseases.
胸腺内阴性选择的发生过程也就是中枢免疫耐受的形成过程，即自身反应性胸腺细胞被克隆清除或处于免疫无能状态的过程。
The process of thymic negative selection is the process of the central immunologic tolerance, namely the process of autoreac-tive thymic cells being deleted or becoming allergy.
阳性选择决定了成熟T细胞的MHC限制性，阴性选择使机体获得自身免疫耐受。
The MHC restriction of t cell is determined in positive selection. The tolerance of t cells to autoantigen is acquired during negative selection.
但这些抗原多属自身抗原，普遍存在免疫原性低，易引起免疫耐受等缺陷。
But most of the antigen was the kind of self-antigen with the defects of poor-immunogenicity and easily-caused immunotolerance.
结论：异种血管内皮生长因子基因重组T7噬菌体疫苗可打破机体对自身vegf的免疫耐受，诱导产生较高水平的特异性抗vegf抗体。
Conclusion: Recombinant T7 phage vaccine expressing xenogenic VEGF can break immunologic tolerance against self-VEGF and induce the producing of specific anti-VEGF antibody.
未成熟T细胞通过TCR-CD3 复合物与自身抗原接合激活上述过程可能与克隆清除的形成机制及自我耐受有关。
Activation of this process in immature T cell by the bindng of the TCR CD3 to self antigens may therefor be the mechanism which produces clonal deletion and consequently self tolerance.
目的：探讨混合胸腺移植诱导移植免疫耐受而不发生自身免疫性疾病的可行性。
Objective:To explore feasibility of inducing immune tolerance and prevention of organ specific autoimmune disease by transplanting with mixed fetal syngeneic or allogeneic and xenogeneic thymus.
近年来通过口服抗原(耐受原)诱导免疫耐受，靶向性治疗自身免疫病的研究日益受到关注。
The therapy of autoimmune diseases by inducing oral immune tolerance has progressed a lot recently.
目的建立实验性自身免疫性脑脊髓炎(eae)动物模型，研究腹腔内注射可溶性髓鞘碱性蛋白(MBP)诱导免疫耐受的作用机制。
Objective to establish the animal model of EAE (experimental autoimmune encephalomyelitis) to study the inducible suppression of EAE by i. p. administration of soluble MBP (myelin basic protein).
对自身免疫耐受产生机制的揭示将为自身免疫病、超敏反应、移植排斥及肿瘤的治疗提供新的策略。
Understanding the mechanisms of self-tolerance will help to find new strategies for treatment of autoimmune disease, hypersensitivity, transplantation rejection and tumor.
对自身免疫耐受产生机制的揭示将为自身免疫病、超敏反应、移植排斥及肿瘤的治疗提供新的策略。
Understanding the mechanisms of self-tolerance will help to find new strategies for treatment of autoimmune disease, hypersensitivity, transplantation rejection and tumor.
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