目的探讨骨肉瘤基因治疗的可行性。
Objective To study the gene therapy for osteosarcoma in vitro.
劳斯肉瘤病毒包含触发肿瘤形成的src基因。
Rous sarcoma virus contains the src gene that triggers tumor formation.
研究了环六亚甲基双乙酰胺对人成骨肉瘤MG-63细胞的增殖和相关基因表达的影响。
In this paper, we studied the effects of HMBA on the proliferation and expression of genes in human osteosarcoma MG-63 cells.
目的：探讨B7 - 1基因转染骨肉瘤细胞能否诱导抗骨肉瘤主动免疫作用。
Objective: To explore whether transfection of osteosarcoma cells with B7-1 gene can induce anti-osteosarcoma active immune response.
骨肉瘤p 53基因多位于外显子GC序列，尤其是外显子7，有别于其他肿瘤好发位点。
The P53 gene mutation site in osteosarcoma was mostly in GC sequence of exon, especially in exon 7, which was different with other tumors.
脑膜血管外皮细胞瘤和间叶软骨肉瘤是一样的吗？：一项关于HEY1 - NCOA2融合基因的研究。
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same? : a study of HEY1-NCOA2 fusion.
目的检测滑膜肉瘤新鲜冰冻标本中的SYT -SSX融合基因，分析融合基因亚型与病理表型之间的关系。
Objective to detect SYT-SSX fusion gene transcripts in fresh-frozen synovial sarcoma specimens and analyze the correlation between histological phenotypes and SYT-SSX subtypes.
结论HSV-TK/GCV基因治疗系统可为骨肉瘤的治疗提供新途径。
Conclusion HSV-TK/GCV gene therapy system may provide a new therapeutic approach for treatment of osteosarcoma.
目的检测肿瘤易感基因tsg101在肉瘤的表达情况，探讨其表达在肉瘤发生中的可能作用。
Objective to detect the expression of the tumor susceptibility gene TSG101 in sarcoma to investigate the potential role of TSG101 in the pathogenesis of sarcoma.
方法观察骨肉瘤中成骨细胞相关基因表达的频率、特异性，以及骨肉瘤成骨细胞表型与生物学行为的关系。
Methods osteoblast related gene expression frequency, specialty, and the relationship between osteoblastic phenotype and biological behavior of osteosarcoma were studied.
目的从分子水平探讨骨形态发生蛋白2 (BMP - 2)基因对骨肉瘤生物学行为的影响，并为骨肉瘤的基因治疗提供理论依据。
Objective to probe into the mechanisms of bone morphogenetic protein-2 (BMP-2) in osteosarcoma and to provide basis for gene therapy.
背景与目的：骨肉瘤转移机制密切相关的基因筛选是骨科领域研究的难点。
Background and purpose: the screening of the genes being related closely with the mechanism of osteosarcoma metastasis was a difficult point in the realm of orthopaedics.
结果肿瘤易感基因tsg101在肉瘤中的表达率较低，仅为17.5%。
Results The expression of TSG101 showed low level in sarcomas, with only 17.5% positive rate.
结论SYT SSX融合基因表达可作为诊断滑膜肉瘤新的分子诊断指标。
Conclusions SYT-SSX is a reliable index for the molecular pathological diagnosis of synovial sarcoma.
目的：研究重组纤溶酶原激活剂抑制剂-2基因表达对纤维肉瘤细胞超微结构的影响。
The effect of recombinant PAI-2 on the ultrastructure of fibrosarcoma-transplanted tumor was investigated in this study.
这项工作非常重要，因为它为在基因水平研究横纹肌肉瘤的病因提供了简单的动物模型，这种模型就是果蝇。
This work is important because it provides a simple organism, the fruit fly, as a model for analyzing the genetic causes of rhabdomyosarcoma.
我们测序了10例恶性叶状肿瘤的510个癌症相关基因，其中5例伴有脂肪肉瘤样分化，1例伴有粘液软骨肉瘤样分化。
We sequenced 510 cancer-related genes in 10 malignant phyllodes tumors, including 5 tumors with liposarcomatous differentiation and 1 with myxoid chondrosarcoma-like differentiation.
在回顾性复习这些病例的基础上，作者发现伴 ZC3H7B-BCOR 基因融合的ESS构成了高级别 ESS一种新的亚型，并且该亚型与黏液样型平滑肌肉瘤在形态学上有显著的重叠。
On the basis of the review of these cases, we find that ESS with ZC3H7B-BCOR fusion constitutes a novel type of high-grade ESS and shares significant morphologic overlap with myxoid leiomyosarcoma.
免疫组化结果也促使我们对肉瘤融合(FUS)基因进行排序。
Immunohistochemical findings prompted us to sequence the fused in sarcoma (fus) gene.
然而，最新的检测报道发现在很大一部分骨旁骨肉瘤中有GNAS突变，对该基因突变的特异性提出了质疑。
However, the recent report of GNAS mutations being detected in a significant proportion of parosteal osteosarcoma challenges the specificity of this mutation.
结果：人成骨肉瘤MG- 63细胞株接种培养第7天后I型胶原基因表达较高。
Results: in human osteosarcoma cell line MG-63 culture Type I collagen mRNA expression reach a maximum level on days 7.
骨肉瘤是一种多基因病变，应用基因芯片技术有助于发现该肿瘤的基因变化。
It is helpful to apply gene array to find the laws of gene expression and to study the gene-gene interactional relationships in this tumor.
我们报道的唯一一例转移性基底细胞癌肉瘤病例，并对原发肿瘤的两种成分及转移成分进行了第二代基因测序。
Herein, we report a unique case of metastatic basal cell carcinosarcoma, in which we analyzed the 2 components of the primary tumor as well as the metastasis by next-generation sequencing.
我们报道的唯一一例转移性基底细胞癌肉瘤病例，并对原发肿瘤的两种成分及转移成分进行了第二代基因测序。
Herein, we report a unique case of metastatic basal cell carcinosarcoma, in which we analyzed the 2 components of the primary tumor as well as the metastasis by next-generation sequencing.
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