结论:APS有可能成为既能促进正常造血,又能抑制白血病等肿瘤细胞增殖,并诱导其凋亡或分化的天然诱导剂。
Conclusion: APS may not only promote normal hematopoiesis, but also inhibit the proliferation of leukemia cell and it can be a natural inducer for therapy of malignant tumor.
诱导分化是指在分化诱导剂的存在下,恶性肿瘤细胞的形态、生物学或生物化学方面的诸多标志均向正常细胞的方向分化,甚至完全转变成正常细胞。
By derived differentiation, we mean that under the effect of differentiation inducer, malignant tumor cell has the tendency to differentiate to normal cell, even became normal cells.
当这些细胞开始不受控制地分化,形成肿块或肿瘤时,问题就来了。
The problem arises when these cells start to divide uncontrollably, and form lumps or growths.
结果表明,突变型P53蛋白的表达与脑肿瘤的组织类型,分化程度及细胞的增殖有关,而它的高表达又可能是肿瘤恶性表型或转移的标志之一。
This results showed that mutant P53 expression was associated with a high Ki-67 LI and high histologic grade of tumors. P53 overexpression might be a genetic marker of tumor malignancy.
结果表明,突变型P53蛋白的表达与脑肿瘤的组织类型,分化程度及细胞的增殖有关,而它的高表达又可能是肿瘤恶性表型或转移的标志之一。
This results showed that mutant P53 expression was associated with a high Ki-67 LI and high histologic grade of tumors. P53 overexpression might be a genetic marker of tumor malignancy.
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