现就线粒体功能障碍与AS形成之间的关系进行综述。
Here is to review on the correlation of mitochondrial dysfunction and the pathogenesis of AS.
近年来，有关线粒体功能障碍与AS关系的研究日益增多。
Recently, there are more research focusing on the relationship between mitochondrial dysfunction and pathogenesis of AS.
此损害导致大量多泛素化蛋白的积聚和线粒体功能障碍（被公认的细胞死亡的媒介）。
This impairment resulted in massive accumulation of polyubiquitinated proteins and of dysfunctional mitochondria which are the putative mediators of cell death.
在另一方面，线粒体功能障碍可导致许多神经退行性条件，以及代谢性疾病，如糖尿病。
On the other hand, mitochondrial dysfunction can lead to many neurodegenerative conditions as well as metabolic diseases such as diabetes.
因此，治疗线粒体功能障碍以及开发定位于线粒体的疗法已成为科学研究的首要重点不足为奇。
Hence, it is not surprising that treatment of mitochondrial dysfunction and development of mitochondrion-targeted therapeutics have become a primary focus of scientific research.
早有已有研究证明线粒体功能障碍与多种很多其他神经系统疾病，包括帕金森病、阿尔茨海默病、精神分裂症及双相情感障碍有关。
Dysfunction in mitochondria already is associated with a number of other neurological conditions, including Parkinson's disease, Alzheimer's disease, schizophrenia and bipolar disorder.
缺氧缺血新生鼠嵴膜密度的减少与线粒体呼吸功能、能量合成功能障碍密切相关。
The decrease of mitochondrial cristal membrane density of hypoxic ischemic newborn rats was tightly related to dysfunction of mitochondrial respiration and energy synthesis.
缺氧缺血新生鼠嵴膜密度的减少与线粒体呼吸功能、能量合成功能障碍密切相关。
The decrease of mitochondrial cristal membrane density of hypoxic ischemic newborn rats was tightly related to dysfunction of mitochondrial respiration and energy synthesis.
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