目的：探讨肾疏宁防治系膜基质硬化的细胞分子机制。
Objective: To study the cellular and molecular mechanism of Shenshuning (SSN) in preventing mesangial sclerosis.
系膜细胞核不规则，胞质内线粒体肿胀，系膜基质正常。
Mesangial cell nuclei showed irregular shape and mitochondria swelled, stroma was normal.
有关糖尿病肾病发病机制的研究，人们早先关注的是肾脏系膜基质堆积和肾小球基底膜增厚。
Research on the mechanism of diabetic nephropathy was initially focused on the mesangial matrix and glomerular basement membrane.
病理表现为系膜基质增多，肾小球基底膜上皮下透明物质积聚以及毛细血管袢与包氏囊粘连等改变。
The pathological character shows that messegium increased, transparency material of the glomerulus basement membrane epithelium accumulates, capillary and capsular adheres.
提示，临床上LMWH能通过对增生性肾炎患者系膜细胞增殖和系膜基质积聚的抑制作用而发挥效应。
The effect of LMWH on patients with proliferative glomerulonephritis may be associated with inhibiting the proliferation of mesangial cell and the accumulation of mesangial matrix.
目的观察缓激肽（BK）对高糖浓度下肾小球系膜细胞增殖和细胞外基质分泌的影响。
Objective To observe the effect of bradykinin(BK) on kidney mesangial cell multiplication and extracellular matrix secretion under high glucose environment.
目的探讨“延肾胶囊”对残肾肾小球系膜细胞凋亡及其细胞外基质代谢的影响。
Objective To elucidate the effect of Yan-Shen Capsule on glomerular mesangial cell apoptosis and extracellular matrix metabolism of remnant kidney.
肾小球系膜：基质轻度增生。发现部分电子致密物质，但这不是典型的免疫类沉积。
Mesangium: Possible mild increase in matrix. Some electron dense material identified but this is not typical of immune type deposits.
结论PC - 1nf融合蛋白能抑制大鼠系膜细胞增殖、诱导细胞凋亡及减少细胞外基质合成。
Conclusion: PC-1NF fusion protein may inhibit the proliferation, induce apoptosis and decrease ECM production of RMC.
肾血宁胶囊能抑制肾小球系膜细胞的增殖，并通过下调FN在肾内的表达，抑制肾小球细胞外基质的积聚；
Shen-Xue-Ning capsule can inhibit mesentery cell hyperplasia and extracellular matrix collection of glomerular by regulating FN in kidney;
肾小球系膜细胞(GMC)的增殖通过影响细胞外基质(ecm)的分泌和对肾小球毛细血管的机械损伤而在肾小球硬化过程中发挥着重要作用。
BackgroundThe GMC proliferation plays an important role in glomerular sclerosis by influencing the ECMs secretion and mechanical injury on the glomerular capillaries.
结论：非诺贝特能抑制高糖培养的系膜细胞增殖，减少胞外基质合成，增加胞外基质的降解。
Conclusion: Fenofibrate can inhibit high glucose-induced proliferation of mesangial cells, decrease synthesis of extracellular matrix, and increase degradation of extracellular matrix.
结论：非诺贝特能抑制高糖培养的系膜细胞增殖，减少胞外基质合成，增加胞外基质的降解。
Conclusion: Fenofibrate can inhibit high glucose-induced proliferation of mesangial cells, decrease synthesis of extracellular matrix, and increase degradation of extracellular matrix.
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