能否请您谈谈抗B细胞疗法诱导移植耐受治疗策略的可能性？
Can you talk about the possibilities of strategies for B cell-directed therapy for the induction of transplant tolerance?
目的：通过异基因鼠联体共生诱导心脏移植耐受并探讨其耐受机理。
Objective: to induce cardiac transplantation tolerance by parabiosis in allogeneic rats and study the mechanism of the allograft tolerance.
目的研究有效诱导异种骨髓移植耐受的方法和对异基因骨髓移植重建的影响。
Objective to study an effective method in inducing donor specific tolerance as well as the effects on hematopoietic reconstitution after xenogeneic-bone marrow transplantation.
综述目的：人们对于移植耐受的理解在近年发生了很多次范式转换（思维转换）。
Purpose of review: Our understanding of transplantation tolerance has undergone numerous paradigm shifts in recent years.
结论嵌合状态与肾移植耐受存在明显相关性，克隆不应答、抑制细胞参与了耐受的形成。
Several other mechanisms may by theorized for the induction of tolerance in this renal transplant model, including clonal anergy and suppressive cells.
目的探索建立受体针对供体抗原特异性T淋巴细胞克隆，转入自杀基因诱导移植耐受的可行性。
Objective to explore the feasibility that the recipient against donor antigen specific t lymphocytes clones are formed, and the suicide genes are induced into the clone.
目的：在进行心脏移植手术的同时，经门静脉输注供体脾细胞诱导移植耐受，并探讨其耐受机制。
Objective: to induce cardiac transplantation tolerance in rat by perioperative injection of spleen cells into portal vein, and to study the mechanism concerning transplantation tolerance.
结论：本诱导方案能明显延长异基因异位大鼠心脏移植物存活时间，是便于临床推广应用的一种有效方法，该移植耐受的形成涉及多种机制。
Conclusions: The tolerance induction protocol significantly prolonged cardiac allograft survival in rat, and it appears to be worthy of a clinical trial. This tolerance involved multiple mechanisms.
在免疫耐受网络系统的支持下，现在已经开展胰岛移植前瞻性多中心试验研究。
Islet cell transplantation now forms the basis of a prospective multicenter trial under the aegis of the Immune Tolerance Network.
结论：赛尼哌用于肾移植的免疫诱导治疗，可以预防和减少急性排斥反应的发生，安全性和耐受性好。
CONCLUSION: Zenapax used for immunity induction of renal transplantation can prevent and reduce the occurrence of acute reject reaction, it has safety and good tolerance.
在产生免疫耐受的移植物中可发现调节性T淋巴细胞，并对移植组织具有保护性作用。
Regulatory T cells can be found in tolerated grafts and contribute to the acquisition of a state of privilege in those tissues.
目的：观察小剂量FK506作用下同种脾组织移植对大鼠肝移植术后免疫耐受的影响，探讨其可能的机制。
Objective:To investigate the influence of allogeneic spleen tissue transplantation with low-dose FK506 on allograft tolerance in rats receiving orthotopic liver transplant and the related mechanism.
另外，肾移植患者的遗传背景、身体状况和基础疾病各不相同，造成其对免疫抑制治疗的耐受程度不一样。
Furthermore the kidney transplant patients had different genetic background and body constitution, and basic diseases. So the tolerance of each one to the immunosuppression treatment was variant.
目的了解异基因骨髓注射在大鼠小肠移植中的免疫耐受作用和意义。
ObjectiveTo investigate the immune tolerance function and significance of allogene bone marrow injection to the small intestines transplantation of rats.
现阶段诱导免疫耐受的有效方法，主要有供者特异性输血和供者特异性骨髓移植。
At present the main effective strategies of inducing immune tolerance are donor specific blood transfusion and donor specific bone marrow transplantation.
目的利用大鼠异位心脏移植模型，探讨门静脉注射供体脾细胞诱导免疫耐受的机制。
Objective on the rat model of heterotopic heart transplantation, the mechanism of immune tolerance induced by portal venous injection of donor spleen cells was studied.
结论：同供体肾移植及骨髓细胞输注是一种可行的诱导免疫耐受的方法，且简便安全。
Conclusion: Donor bone marrow transfusion was safe and beneficial. It could induce specific immunologic tolerance in the renal allograft recipients.
皮肤移植会出现典型的快速排斥反应，通过这个途径他延长了对皮肤移植物的耐受，当然有时也不一定。
Using this approach, he has been able to prolong acceptance of skin grafts, which are typically rapidly rejected, sometimes indefinitely.
目的探讨异基因小鼠髓腔内骨髓移植(IBM - BMT)诱导免疫耐受的效果。
Objective to explore the effect of allogeneic intra-bone marrow bone marrow transplantation (IBM-BMT) on the induction of immune tolerance.
结论有些长期携带功能良好移植肾的患者已经获得对供者细胞特异的免疫耐受状态。
Conclusion Some of the patients carrying long - term and well - functioning renal grafts had become immunologic tolerant to donor cells.
结论胸腺内注射异基因MHC抗原可诱导大鼠对异体坐骨神经移植的特异性免疫耐受。
Conclusion Intrathymus injection of allogene MHC antigen might induce specific immune tolerance to sciatic nerve allografts in mice.
同时，通过处理共刺激信号的方法诱导免疫耐受在异体手移植中具有一定的应用前景。
Meanwhile co-stimulating signal induced immunological tolerance is proved promising for the application of hand transplantation.
目的探索混合皮肤移植中，自体皮岛诱发移植免疫耐受的免疫机制。
Aim to explore the mechanism of the immune tolerance induced by the auto-islets in the intermingled skin grafting.
结论：胸腺移植对诱导免疫耐受、提高异种胰岛移植物存活有一定作用。
Concluson: Thymus transplantation is effective to induce xenograft tolerance and improve the functional survival time of islet xenograft.
方法分析近年来有关胰腺移植免疫耐受研究进展的文献报道。
Methods Relevant literatures about immune tolerance in pancreas transplantation, which were published recently domestic and abroad were collected and reviewed.
目前，移植领域的一个重要方向就是诱导多机制起作用的免疫耐受，防治人体对同种异体器官的慢性排斥反应。
At present, the immunological tolerance in transplantation induced by multi-mechanisms, to inhibit the chronic graft rejection, represents an important trend in the field of transplantation.
卡泊芬净一线治疗异基因造血干细胞移植患者侵袭性真菌病是有效且可耐受的。
Caspofungin first-line therapy was effective and well tolerated in allogeneic hematopoietic SCT patients with mycologically documented IA.
卡泊芬净一线治疗异基因造血干细胞移植患者侵袭性真菌病是有效且可耐受的。
Caspofungin first-line therapy was effective and well tolerated in allogeneic hematopoietic SCT patients with mycologically documented IA.
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