目的：改进盐酸舍曲林的合成工艺。
Objective: To improve synthesis of sertraline hydrochloride.
盐酸舍曲林晶形v和VI可通过结晶由盐酸舍曲林或舍曲林碱来制备。
Sertraline hydrochloride Forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization.
根据本发明，盐酸舍曲林晶形II可直接由舍曲林碱或扁桃酸舍曲林制备。
Accordnig to the present invention, sertraline hydrochloride Form II may be produced directly for sertraline base or sertraline mandelate.
它还可以由盐酸舍曲林溶剂化物和水合物晶形以及结晶形成新的溶剂系统来制备。
It can also be synthesized from the solvent system of sertraline-hydrochloride solvate and hydrate crystal and the crystallization solvate.
它还可以由盐酸舍曲林溶剂化物和水合物晶形以及结晶形成新的溶剂系统来制备。
It may also be produced from sertraline hydrochloride solvate and hydrate forms, and crystallized form new solvent systems.
盐酸舍曲林晶形VII可通过将盐酸舍曲林多晶型物v悬浮在水中继而过滤来制备。
Sertraline hydrochloride form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration.
也公开了含有盐酸舍曲林晶形II、III和V -X的药物组合物，和应用上述药物组合物治疗的方法。
Pharmaceutical compositions containing sertraline hydrochloride Forms II, III and V through X, the methods of treatment using such pharmaceutical compositions are also disclosed.
也公开了含有盐酸舍曲林晶形II、III和V -X的药物组合物，和应用上述药物组合物治疗的方法。
Pharmaceutical compositions containing sertraline hydrochloride Forms II, III and V through X, the methods of treatment using such pharmaceutical compositions are also disclosed.
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