根据FDA提供的资料,拉帕替尼通过进入表达HER2蛋白的细胞,阻滞促进肿瘤生长的信号。
According to the FDA, Tykerb inhibits tumor growth by going inside cells containing the HER2 protein and blocking signals that promote tumor growth.
临床关联性:采用与临床相关的手术行脊柱半骺阻滞的实验方法表明在生长板结构建立了一个梯度。
Clinical Relevance: A method of spinal hemiepiphysiodesis with use of a clinically relevant procedure has been shown to create a gradient in growth plate structure.
它通过阻滞被称为肿瘤繁殖和血管生成的两个过程(引起肿瘤的生长和扩散)来发挥作用。
It works by blocking 2 basic processes that cause tumors to grow and spread. These processes are called proliferation and angiogenesis.
这种药物可针对细胞内的关键靶信号途径从而阻滞或延缓肿瘤生长。
Such drugs target key signaling pathways within cells that can stop or slow tumor growth.
该药能阻滞癌细胞上的受体,正常情况下,这些受体与雌激素相连,因此这种药能阻止雌激素刺激肿瘤的生长。
The drug blocks receptors on cancer cells that normally bind with estrogen, and thereby prevents estrogen from stimulating tumors to grow.
结论:向胃癌细胞中导入外源性FHIT基因可以抑制肿瘤细胞增殖,诱导细胞凋亡并引起细胞生长周期阻滞。
Conclusions: Transfecting the exogenous FHIT gene into gastric cancer cells can suppress the proliferation of tumor cells, and can also induce apoptosis and cell cycle arrest.
目的:临床试验中对组蛋白脱乙酰基酶阻滞剂(HDACi)的研究目的在于诱导细胞分化,生长停止,和肿瘤细胞的凋亡。
Purpose: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells.
在这方面我正在研究的一种思路就是,如果一个患者只有7三体,我们可以用表皮生长因子受体阻滞剂治疗6个月,观察是否能根除这种克隆。
One of the ideas that I am working on is that if a patient has trisomy 7 only we can give them an epidermal growth factor receptor inhibitor for six months and see if we can eradicate those clones.
在这方面我正在研究的一种思路就是,如果一个患者只有7三体,我们可以用表皮生长因子受体阻滞剂治疗6个月,观察是否能根除这种克隆。
One of the ideas that I am working on is that if a patient has trisomy 7 only we can give them an epidermal growth factor receptor inhibitor for six months and see if we can eradicate those clones.
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