方法：以3-三氟甲基- 4-氰基苯胺和2- 甲基丙烯酰氯为起始原料经过酰化、 环氧化、取代和氧化四步反应合成比卡鲁胺。

Methods:Bicalutamide was prepared from 4-cyano-3-(trifluoromethyl) aniline and 2-methylacryloyl chloride by four steps: acylation, cyclization, substitution, and oxidization.

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以2-氰基-4-硝基苯胺为原料，用直接卤化法研制成2-氰基-4-硝基-6-氯苯胺、2-氰基-4-硝基-6-溴苯胺、和2-氰基-4-硝基-6-碘苯胺。

With 2-cyano-4-nitro-aniline as raw material, 2-cyano-4-nitro-6-halogen- anilines have been prepared by direct halogenation.

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以2-氰基-4-硝基苯胺为原料，用直接卤化法研制成2-氰基-4-硝基-6-氯苯胺、2-氰基-4-硝基-6-溴苯胺、和2-氰基-4-硝基-6-碘苯胺。

With 2-cyano-4-nitro-aniline as raw material, 2-cyano-4-nitro-6-halogen- anilines have been prepared by direct halogenation.

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