结果：在164个家庭成员中， 94个存在核纤层蛋白A/C基因突变。
Results: Of the 164 family members, 94 had LMNA gene mutations.
型核纤层蛋白决定细胞核的大小及形状，与细胞核的稳定性、染色质结构以及基因表达有关。
Lamin proteins are thought to determine the size and shape of cell nuclei and to be involved in nuclear stability, chromatin structure and gene expression.
与之相比，在核纤层蛋白相关的异染色质区域以及位于细胞核中部的转录活跃区域并不会得到病毒的青睐。
This region contains a series of cellular genes, which are preferentially targeted by the virus, and characterized by the presence of active transcription chromatin marks before viral infection.
表明，UL34基因对病毒的早期包装、成熟和出芽以及对UL31蛋白和核纤层蛋白在感染细胞中的正确定位都具有重要作用。
Then, the important roles of the gene in viral primary envelopment, mature and budding, proper location of the UL31 protein and lamin protein in cells infected with the virus were pointed out.
表明，UL34基因对病毒的早期包装、成熟和出芽以及对UL31蛋白和核纤层蛋白在感染细胞中的正确定位都具有重要作用。
Then, the important roles of the gene in viral primary envelopment, mature and budding, proper location of the UL31 protein and lamin protein in cells infected with the virus were pointed out.
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