这并不是完全的抗药性表现,也就是说它们没有任何的抗药性突变。
They're not exactly antibiotic resistant, so they don't have any special drug-destroying mutations.
没有被抗生素完全杀死的细菌会突变并产生抗药性。
Bacteria that are not killed entirely by an antibiotic will mutate and become resistant to it.
这类持续存在的病原体虽然其本质不同于那些通过基因突变而产生抗药性的病原体,但是它们的存在都是不小的问题。
Persistent bugs are different from those that develop antibiotic resistance through genetic mutations, but may be just as much of a problem.
科学家在论文中写到“消灭p53突变体能够降低抗药性,引出临床癌症治疗的新方法。”
The researchers write that “depletion of mutant p53 may reduce drug resistance and lead to new strategies for treating cancer in the clinic.”
可以推断,针对Xalkori的抗药性是由于这三个基因中的一个或多个发生了突变导致的结果。
Presumably, resistance to Xalkori is being caused by disabling mutations in one or more of these genes.
有一种突变的基因能够调控肿瘤细胞使其在化疗药物发挥作用前将药物泵出细胞外,从而具有抗药性。
One probably made the cancer drug-resistant by enabling the tumor cells to pump chemotherapy drugs right out of the cell before they could do their work.
抗叶酸类抗疟药的抗药性机制已基本搞清,与其作用靶酶二氢叶酸还原酶或二氢蝶酸合成酶基因点突变相关。
The molecular mechanism of resistance to the antifolates has been well characterisied and is due to structural changes in the target enzymes resulting from the point mutations of DHFR or DHPS gene.
通过构建更精确的整合酶模型,这技术使未来未来搜寻新的药物分子成为可能,这些新药物分子将能通过稳定病毒蛋白酶的结构来抑制突变病毒的抗药性。
By producing a more accurate model of integrase, the research allows further searches for new drug molecules that will inhibit the mutant drug resistant forms of this enzyme, as well.
其中一些基因突变直接与抗药性有关,其他突变使得寄生虫更容易出现抗性。
Some of these genetic changes are links directly to resistance while others make the parasites more accessible to it.
将抗药突变体在无药培养基上继代培养9代后,其抗性倍数逐渐下降,抗药性可能不能稳定遗传。
The resistant rate of resistant mutants gradually decreased after 9 generations of subcultures in the absence of fungicides and the resistance obtained could be unstable.
将抗药突变体在无药培养基上继代培养9代后,其抗性倍数逐渐下降,抗药性可能不能稳定遗传。
The resistant rate of resistant mutants gradually decreased after 9 generations of subcultures in the absence of fungicides and the resistance obtained could be unstable.
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